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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >GSK-3 inhibitors >1-AZAKENPAULLONE

1-AZAKENPAULLONE

1-AZAKENPAULLONE Structure
CAS No.
676596-65-9
Chemical Name:
1-AZAKENPAULLONE
Synonyms
azakenpaullone;1-AZAKENPAULLONE;1-Azakenpaullone (1-Akp);1-AZAKENPAULLONE USP/EP/BP;InSolution? 1-Azakenpaullone;1-Azakenpaullone - CAS 676596-65-9 - Calbiochem;InSolution 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem;9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;Pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 9-broMo-7,12-dihydro-;1-Azakenpaullone 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one
CBNumber:
CB6803762
Molecular Formula:
C15H10BrN3O
Molecular Weight:
328.16
MOL File:
676596-65-9.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:51:00
Request For Quotation

1-AZAKENPAULLONE Properties

Melting point >290°C (dec.)
Boiling point 648.8±50.0 °C(Predicted)
Density 1.655±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >10mg/mL
pka 13.36±0.20(Predicted)
form Tan solid
color gray-brown
InChI InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
InChIKey NTSBZVCEIVPKBJ-UHFFFAOYSA-N
SMILES N1C2=C(C=C(Br)C=C2)C2CC(=O)NC3=CC=CN=C3C1=2

SAFETY

Risk and Safety Statements

WGK Germany  2

1-AZAKENPAULLONE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A3734 1-Azakenpaullone ≥97% (HPLC) 676596-65-9 1MG ₹14516.33 2022-06-14 Buy
Sigma-Aldrich(India) A3734 1-Azakenpaullone ≥97% (HPLC) 676596-65-9 5MG ₹58054.48 2022-06-14 Buy
Sigma-Aldrich(India) 191501 InSolution 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem A Kenpaullone analog that acts as a potent and ATP-competitive inhibitor of GSK-3&beta. 676596-65-9 500μG ₹6000 2022-06-14 Buy
Product number Packaging Price Buy
A3734 1MG ₹14516.33 Buy
A3734 5MG ₹58054.48 Buy
191501 500μG ₹6000 Buy

1-AZAKENPAULLONE Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

A selective inhibitor of glycogen synthase kinase-3β.

General Description

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 μM and 4.2 μM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

Enzyme inhibitor

This cell-permeable protein kinase inhibitor (FW = 328.17 g/mol; CAS 676596-65-9: Solubility: 66 mg/mL DMSO; <1 mg/mL H2O), also named 9-bromo-7,12-dihydro-pyrido[3,2’:2,3]azepino[4,5-b]indol-6(5H)-one, selectively and potently targets glycogen synthase kinase 3β, or GSK3β (IC50 = 18 nM) with 100x less inhibitory action against cyclin-dependent kinases (CDKs). 1-Azakenpaullone has become a gold standard for GSK3 inhibition.

1-AZAKENPAULLONE Preparation Products And Raw materials

Raw materials

Preparation Products

1-AZAKENPAULLONE Suppliers

Global( 85)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Meike meditech (Foshan) Co.,Ltd +86-0757-22239986 +86-18029359586 China 1134 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Meike meditech (Foshan) Co.,Ltd 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58

1-AZAKENPAULLONE Spectrum

1-AZAKENPAULLONE(676596-65-9)1HNMR

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1-AZAKENPAULLONE 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one Pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 9-broMo-7,12-dihydro- InSolution? 1-Azakenpaullone 1-Azakenpaullone 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one InSolution 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem azakenpaullone 1-AZAKENPAULLONE USP/EP/BP 1-Azakenpaullone (1-Akp) Glycogen synthase kinase-3,1 Azakenpaullone,GSK-3,1-Azakenpaullone,1Azakenpaullone,Glycogen synthase kinase 3,Inhibitor,inhibit,1-Akp 676596-65-9 C15H10BrN3O All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators