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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >GSK-3 inhibitors >SB 415286

SB 415286

SB 415286 Structure
CAS No.
264218-23-7
Chemical Name:
SB 415286
Synonyms
CS-228;SB-41528;SB 415286;SB-415286; SB415286;SB 415286 USP/EP/BP;7-L-Alanine-cyclosporin A;3-[(3-CHLORO-4-HYDROXYPHENYL)AMINO]-4-(2-NITROPHENYL)-1H-PYRROL-2,5-DIONE;3-[(3-CHLORO-4-HYDROXYPHENYL)AMINO]-4-(2-NITROPHENYL)-1H-PYRROLE-2,5-DIONE;1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)aMino]-4-(2-nitrophenyl)-
CBNumber:
CB7325007
Molecular Formula:
C16H10ClN3O5
Molecular Weight:
359.72
MOL File:
264218-23-7.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

SB 415286 Properties

Boiling point 595.8±50.0 °C(Predicted)
Density 1.647
storage temp. -20°C
solubility DMSO: 16 mg/mL
form Yellow Solid.
pka 6.81±0.60(Predicted)
color yellow to orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

SB 415286 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S3567 SB 415286 ≥98% (HPLC) 264218-23-7 5MG ₹16260 2022-06-14 Buy
Sigma-Aldrich(India) S3567 SB 415286 ≥98% (HPLC) 264218-23-7 25MG ₹58700 2022-06-14 Buy
Product number Packaging Price Buy
S3567 5MG ₹16260 Buy
S3567 25MG ₹58700 Buy

SB 415286 Chemical Properties,Uses,Production

Description

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis, and inflammation. SB-415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. As a result of GSK3 inhibition, SB-415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 μM. SB-415286 also protects primary neurons from death induced by the PI3-kinase pathway.

Uses

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

Definition

ChEBI: A member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively.

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 31 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

SB 415286 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 415286 Suppliers

Global( 101)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58

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1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)aMino]-4-(2-nitrophenyl)- SB 415286 3-[(3-CHLORO-4-HYDROXYPHENYL)AMINO]-4-(2-NITROPHENYL)-1H-PYRROLE-2,5-DIONE 3-[(3-CHLORO-4-HYDROXYPHENYL)AMINO]-4-(2-NITROPHENYL)-1H-PYRROL-2,5-DIONE 7-L-Alanine-cyclosporin A SB 415286 USP/EP/BP SB-41528 CS-228 SB-415286; SB415286 264218-23-7 C16H10N3O5Cl Cell Signaling and Neuroscience Cell Biology BioChemical Serine/Threonine Kinase Inhibitors Glycogen Synthase Kinase 3 (GSK3) Kinase/Phosphatase Biology Protein Kinase Inhibitors PI3K/Akt/mTOR PI3K mTOR Akt