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WIN 55,212-2 MESYLATE

WIN 55,212-2 MESYLATE Structure
CAS No.
131543-23-2
Chemical Name:
WIN 55,212-2 MESYLATE
Synonyms
WIN55;CS-754;WIN 55,212-2;212-2Mesylate;WIN552122;WIN-552122;WIN 55,212-2 MESYLATE;R(+)-WIN 55,212-2 MESYLATE;WIN 55212-2 methanesulfonate;(R)-(+)-WIN 55,212-2 mesylate salt;WIN552122;WIN-552122;(R)-(+)-WIN 55212
CBNumber:
CB8335502
Molecular Formula:
C28H30N2O6S
Molecular Weight:
522.62
MOL File:
131543-23-2.mol
MSDS File:
SDS
Modify Date:
2024/3/22 14:56:24
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WIN 55,212-2 MESYLATE Properties

storage temp. Store at +4°C
solubility 0.1 M HCl: 0.25 mg/mL
form solid
color white to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey FSGCSTPOPBJYSX-OZYVVJTJNA-N
SMILES S(O)(=O)(=O)C.C(N1CCOCC1)[C@@H]1COC2=CC=CC3C(C(C4=CC=CC5=CC=CC=C45)=O)=C(C)N1C=32 |&1:12,r|

SAFETY

Risk and Safety Statements

WGK Germany  3

WIN 55,212-2 MESYLATE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) 131543-23-2 25MG ₹47565.05 2022-06-14 Buy
Sigma-Aldrich(India) W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) 131543-23-2 100MG ₹91363 2022-06-14 Buy
Product number Packaging Price Buy
W102 25MG ₹47565.05 Buy
W102 100MG ₹91363 Buy

WIN 55,212-2 MESYLATE Chemical Properties,Uses,Production

Description

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 μM.

Uses

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

General Description

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Biological Activity

Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .

WIN 55,212-2 MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

WIN 55,212-2 MESYLATE Suppliers

Global( 155)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
Hebei Kangcang new material Technology Co., LTD +8615713292910 China 341 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +86-17531190177; +8617531190177 China 5873 58 Inquiry
Shanghai UCHEM Inc. +862156762820 +86-13564624040 China 7034 58 Inquiry
Dorne Chemical Technology co. LTD +86-86-13583358881 +8618560316533 China 3146 58 Inquiry
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. +86-029-86333380 18829239519 China 918 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Supplier Advantage
CHEMSWORTH 30
Hebei Kangcang new material Technology Co., LTD 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Hebei Yanxi Chemical Co., Ltd. 58
Shanghai UCHEM Inc. 58
Dorne Chemical Technology co. LTD 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58

131543-23-2(WIN 55,212-2 MESYLATE)Related Search:

SB216763 WIN 54461 7-Methoxy-3-indolecarboxaldehyde 7-Methoxy-1H-indole 2-Methylindole-3-carboxaldehyde
1-Ethyl-2-methylindole 7-Hydroxyindole 3-Acetylindole 3-Morpholinopropanol 1,2-Dimethylindole
1,2-DIMETHYL-1H-INDOLE-3-CARBOXALDEHYDE 1-Methylindole-3-carboxaldehyde [1-[2-(4-Morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenylmethanone 1-(1-ETHYL-1H-INDOL-3-YL)ETHANONE 2-(1H-PYRROL-1-YL)-1-ETHANAMINE
ASISCHEM W99822 2-(1H-INDOL-1-YL)ETHANAMINE 2-(2-METHYL-1H-INDOL-1-YL)ETHANAMINE
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R(+)-WIN 55,212-2 ,MESYLATE HIGH AFFINIT Y CANNABI (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy 212-2Mesylate WIN55 (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt (R)-(+)-WIN 55,212-2 mesylate salt WIN 552122 mesylate, (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone Methanesulfonate (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1-yl WIN 55212-2 methanesulfonate (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1 (R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE R(+)-WIN 55,212-2 MESYLATE WIN 55,212-2 MESYLATE WIN 55,212-2 (+)-WIN 55,212-2 mesylate - CAS 131543-23-2 - Calbiochem CS-754 WIN552122;WIN-552122 WIN552122;WIN-552122;(R)-(+)-WIN 55212 [(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone Monomethanesulfonate (R)-(+)-WIN 55,212-2 mesylate salt >=98% (HPLC) (R)-(+)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo1,2,3-de-1,4-benzoxazin-6-yl-1-naphthalenylmethan one mesylate 131543-23-2 C28H30N2O6S Cannabinoid receptor Cannabinoid