FLAVOPIRIDOL HYDROCHLORIDE
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FLAVOPIRIDOL HYDROCHLORIDE 속성
- 녹는점
- 169.5-170°C
- 알파
- 24D -1.73 to -3.9°
- 저장 조건
- 2-8°C
- 용해도
- H2O: ~2mg/mL
- 산도 계수 (pKa)
- 5.68 ± 0.06(at 25℃)
- 물리적 상태
- 가루
- 색상
- 흰색에서 밝은 갈색까지
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 증류수 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 131740-09-5
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
FLAVOPIRIDOL HYDROCHLORIDE C화학적 특성, 용도, 생산
개요
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model. It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.화학적 성질
Yellow Powder용도
Flavopiridol hydrochloride hydrate has been used:- as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
- as an RNA polymerase inhibitor to study its effects on hepatic cells
- as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo
정의
ChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p aque formation.FLAVOPIRIDOL HYDROCHLORIDE 준비 용품 및 원자재
원자재
준비 용품
FLAVOPIRIDOL HYDROCHLORIDE 공급 업체
글로벌( 149)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 |
sales06@hbduling.cn | China | 15414 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
TopScience Biochemical | 00852-68527855 |
info@itopbiochem.com | China Hong Kong | 902 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
FLAVOPIRIDOL HYDROCHLORIDE 관련 검색:
CL 82198 HYDROCHLORIDE
Diethanolamine
Uracil
Dihydroxybenzoic acid
Resorcinol
3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid
Dihydrocaffeic acid
Diphenylphosphine oxide
Alisertib (MLN8237)
SNS-032
Dasatinib
PD 0332991 HCl
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
PLX4032
Flavopiridol (Alvocidib) HCl
Flavopiridol
2'-chloroflavone
ROHITUKINE