FLAVOPIRIDOL HYDROCHLORIDE
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- ₹14873.55 - ₹59396.78
- Product name: FLAVOPIRIDOL HYDROCHLORIDE
- CAS: 131740-09-5
- MF: C21H21Cl2NO5
- MW: 438.3
- EINECS:634-346-4
- MDL Number:MFCD26792554
- Synonyms:Flavopiridol (Alvocidib)hcl;Flavopiridol HCI;L-86-8276;2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride;NSC 649890 HCl;(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride;Flavopiridol hydrochloride (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride;Flavopiridol hydrochloride, >=98%
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberF3055
- Product descriptionFlavopiridol hydrochloride hydrate ≥98% (HPLC), powder
- Packaging25MG
- Price₹59396.78
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberF3055
- Product descriptionFlavopiridol hydrochloride hydrate ≥98% (HPLC), powder
- Packaging5MG
- Price₹14873.55
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F3055 | Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder | 25MG | ₹59396.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F3055 | Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder | 5MG | ₹14873.55 | 2022-06-14 | Buy |
Properties
Melting point :169.5-170°C
alpha :24D -1.73 to -3.9°
storage temp. :2-8°C
solubility :H2O: ~2mg/mL
pka :5.68 ± 0.06(at 25℃)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
CAS DataBase Reference :131740-09-5
alpha :24D -1.73 to -3.9°
storage temp. :2-8°C
solubility :H2O: ~2mg/mL
pka :5.68 ± 0.06(at 25℃)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
CAS DataBase Reference :131740-09-5
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Flavopiridol is a synthetic flavonoid based on an extract from Dysoxylum binectariferum which has shown potential for treatment of cancer in vitro. Flavopiridol hydrochloride is a potent inhibitor of cyclin-dependent kinases (primarily Cdk1, Cdk2, and Cdk4) with an IC50 of 100 nM. The (-)-cis form induces apoptosis in particular tumor cells. At nanomolar concentrations, flavoporidol hydrochloride has been shown to reduce rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Treatment of flavopiridol decreased the activities of Cdk2 and potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells.Related product price
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