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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >Aurora Kinase Inhibitors >MLN-8237

MLN-8237

MLN-8237 Structure
  • ₹0
  • Product name: MLN-8237
  • CAS: 1028486-01-2
  • MF: C27H20ClFN4O4
  • MW: 518.92
  • EINECS:1592732-453-0
  • MDL Number:MFCD16621243
  • Synonyms:Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-;MLN-8237 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid;alisertib (auroura A kinase inhibitor);Fluorocyclopentenylcytosine;ALISERTIB (MLN8237);MLN 8237; MLN8237;MLN-8237;4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido-[4,5-e]azepin-2-yl)amino)-2-meth;MLN-823;MLN-8237
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :729.1±70.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
form :solid
pka :4.07±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.

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