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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >(+)-Camptothecin

(+)-Camptothecin

(+)-Camptothecin Structure
  • ₹4700 - ₹77019.88
  • Product name: (+)-Camptothecin
  • CAS: 7689-03-4
  • MF: C20H16N2O4
  • MW: 348.35
  • EINECS:444-280-6
  • MDL Number:MFCD00081076
  • Synonyms:CaMpetothecin;(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;CaMptothecin(NATURAL);4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE;5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA-D-GLUCOPYRANOSIDURONIC ACID;(+)-CAMPTOTHECIN;(s)-droxy ;1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4-hy
Price11 Properties Safety Information Description
11 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 50MG
  • 100MG
  • 250MG
  • 1gm
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberC1495
  • Product description(S)-(+)-Camptothecin
  • Packaging100MG
  • Price₹4700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number208925
  • Product descriptionCamptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem A cell-permeable DNA topoisomerase I inhibitor.
  • Packaging50MG
  • Price₹10670
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9911
  • Product description(S)-(+)-Camptothecin ≥90% (HPLC), powder
  • Packaging100MG
  • Price₹12535.35
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC1495
  • Product description(S)-(+)-Camptothecin
  • Packaging1G
  • Price₹21000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9911
  • Product description(S)-(+)-Camptothecin ≥90% (HPLC), powder
  • Packaging250MG
  • Price₹27582.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9911
  • Product description(S)-(+)-Camptothecin ≥90% (HPLC), powder
  • Packaging1G
  • Price₹77019.88
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number C 0778
  • Product description(S)-(+)-Camptothecin 90%
  • Packaging1gm
  • Price₹59049
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number C 0672
  • Product description(S)-(+)-Camptothecin, ≥98%(HPLC)
  • Packaging1gm
  • Price₹19089
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number C 0672
  • Product description(S)-(+)-Camptothecin, ≥98%(HPLC)
  • Packaging50mg
  • Price₹8604
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number C 0672
  • Product description(S)-(+)-Camptothecin, ≥98%(HPLC)
  • Packaging100mg
  • Price₹9603
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number C 0778
  • Product description(S)-(+)-Camptothecin 90%
  • Packaging100mg
  • Price₹9738
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C1495 (S)-(+)-Camptothecin 100MG ₹4700 2022-05-26 Buy
Sigma-Aldrich(India) 208925 Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem A cell-permeable DNA topoisomerase I inhibitor. 50MG ₹10670 2022-06-14 Buy
Sigma-Aldrich(India) C9911 (S)-(+)-Camptothecin ≥90% (HPLC), powder 100MG ₹12535.35 2022-06-14 Buy
TCI Chemicals (India) C1495 (S)-(+)-Camptothecin 1G ₹21000 2022-05-26 Buy
Sigma-Aldrich(India) C9911 (S)-(+)-Camptothecin ≥90% (HPLC), powder 250MG ₹27582.1 2022-06-14 Buy
Sigma-Aldrich(India) C9911 (S)-(+)-Camptothecin ≥90% (HPLC), powder 1G ₹77019.88 2022-06-14 Buy
ottokemi C 0778 (S)-(+)-Camptothecin 90% 1gm ₹59049 2022-05-26 Buy
ottokemi C 0672 (S)-(+)-Camptothecin, ≥98%(HPLC) 1gm ₹19089 2022-05-26 Buy
ottokemi C 0672 (S)-(+)-Camptothecin, ≥98%(HPLC) 50mg ₹8604 2022-05-26 Buy
ottokemi C 0672 (S)-(+)-Camptothecin, ≥98%(HPLC) 100mg ₹9603 2022-05-26 Buy
ottokemi C 0778 (S)-(+)-Camptothecin 90% 100mg ₹9738 2022-05-26 Buy

Properties

Melting point :260 °C (dec.)(lit.)
alpha :D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point :482.73°C (rough estimate)
Density :1.3112 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :2-8°C
solubility :chloroform/methanol (4:1): 4 mg/mL
form :solid
pka :pKa 10.83 (Uncertain)
color :yellow
Water Solubility :insoluble
Merck :14,1735
BRN :631069
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :VSJKWCGYPAHWDS-FQEVSTJZSA-N
LogP :1.740
CAS DataBase Reference :7689-03-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs at the cleavage site, thus inhibiting religa Camptothecin is a cytotoxic, quinoline alkaloid, discovered as the active principle of extracts from the Chinese tree C. acuminate, that inhibits the DNA enzyme topoisomerase I (Top1). It binds the Top1-DNA cleavage complex, inducing DNA-strand breaks. Camptothecin has strong anti-tumor activity against a wide range of experimental tumors and inhibits both DNA and RNA synthesis in mammalian cells. It displays cytotoxity in HT-29 cells with an IC50 value of 10 nM and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in vitro assays.

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Suppliers and manufacturers

Avra Laboratories Pvt Ltd Himpharm Green Vision Life Sciences Pvt Ltd. Rivashaa Agrotech Biopharma Pvt. Ltd. Ralington Pharma S M Herbals Pvt Ltd Sm Herbals Private Limited Nano Biotech Pvt Ltd Mahinams Import & Export LLP Winmark Herbs & Isolates