10-Hydroxycamptothecin
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- ₹14200 - ₹44804.68
- Product name: 10-Hydroxycamptothecin
- CAS: 19685-09-7
- MF: C20H16N2O5
- MW: 364.35
- EINECS:805-668-4
- MDL Number:MFCD00189425
- Synonyms:Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy ;hydroxy-camptotheci ;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
2 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 25MG
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberH1463
- Product description10-Hydroxycamptothecin
- Packaging1G
- Price₹14200
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPHR2491
- Product descriptionIrinotecan Related Compound A certified reference material, pharmaceutical secondary standard
- Packaging25MG
- Price₹44804.68
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | H1463 | 10-Hydroxycamptothecin | 1G | ₹14200 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | PHR2491 | Irinotecan Related Compound A certified reference material, pharmaceutical secondary standard | 25MG | ₹44804.68 | 2022-06-14 | Buy |
Properties
Melting point :265-270°C
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.More related product prices
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