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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin Structure
  • ₹11600 - ₹58411.7
  • Product name: 7-Ethyl-10-hydroxycamptothecin
  • CAS: 86639-52-3
  • MF: C22H20N2O5
  • MW: 392.4
  • EINECS:643-093-9
  • MDL Number:MFCD06762720
  • Synonyms:7-10-hydroxycamptothecin;(4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione;EHCPT;7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38;10-Hydroxycamptothecin acetate salt ,99%;Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione);SN 38(7-Ethyl-10-hydroxycaMptothecin)
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 20MG
  • 50MG
  • 100MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberE0748
  • Product description7-Ethyl-10-hydroxycamptothecin
  • Packaging100MG
  • Price₹11600
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH0165
  • Product description7-Ethyl-10-hydroxycamptothecin ≥98% (HPLC), powder
  • Packaging10MG
  • Price₹16692.15
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberE0748
  • Product description7-Ethyl-10-hydroxycamptothecin
  • Packaging1G
  • Price₹28400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2718
  • Product descriptionIrinotecan Related Compound B Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 20?mg
  • Packaging20MG
  • Price₹56971.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH0165
  • Product description7-Ethyl-10-hydroxycamptothecin ≥98% (HPLC), powder
  • Packaging50MG
  • Price₹58411.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) E0748 7-Ethyl-10-hydroxycamptothecin 100MG ₹11600 2022-05-26 Buy
Sigma-Aldrich(India) H0165 7-Ethyl-10-hydroxycamptothecin ≥98% (HPLC), powder 10MG ₹16692.15 2022-06-14 Buy
TCI Chemicals (India) E0748 7-Ethyl-10-hydroxycamptothecin 1G ₹28400 2022-05-26 Buy
Sigma-Aldrich(India) PHR2718 Irinotecan Related Compound B Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 20?mg 20MG ₹56971.98 2022-06-14 Buy
Sigma-Aldrich(India) H0165 7-Ethyl-10-hydroxycamptothecin ≥98% (HPLC), powder 50MG ₹58411.7 2022-06-14 Buy

Properties

Melting point :217 °C
Boiling point :810.3±65.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
refractive index :21.5 ° (C=0.2, THF)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL
form :powder
pka :9.13±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey :FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES :N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference :86639-52-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

SN-38 is the active metabolite of irinotecan , a derivative of the alkaloid camptothecin , and acts as a potent inhibitor of DNA topoisomerase I. It is formed by the hydrolysis of irinotecan by carboxylesterases and metabolized through glucuronidation by UDP glucuronosyl transferase 1A1. SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM).

More related product prices

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Suppliers and manufacturers

Molkem Chemicals SUJALAM CHEMICALS JSK Chemicals Varanous Labs Pvt Ltd Rivashaa Agrotech Biopharma Pvt. Ltd. Avra Laboratories Pvt Ltd Aktinos Pharma Pvt Ltd Manus Aktteva Trignokem International TCI Chemicals (India) Pvt. Ltd.