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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Proteasome inhibitors >MLN9708

MLN9708

MLN9708 Structure
  • ₹0
  • Product name: MLN9708
  • CAS: 1201902-80-8
  • MF: C20H23BCl2N2O9
  • MW: 517.12
  • EINECS:-0
  • MDL Number:MFCD18251437
  • Synonyms:4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;MLN9708;MLN9708,MLN-9708,MLN 9708;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid MLN9708;Ixazomib Citrate;MLN9708;MLN-9708;4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dio
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>227°C (dec.)
Density :1.47
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka :1.92±0.20(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MLN9708 is an orally bioavailable prodrug of the second-generation proteasome inhibitor MLN2239 . This prodrug rapidly hydrolyzes in plasma to the biologically active form, which inhibits the β5 chymotryptic-like subunit of the 20S proteasome (IC50 = 3.4 nM; Ki = 0.93 nM in cell-free assays). It inhibits the β1 caspase-like and β2 trypsin-like proteolytic sites with IC50 values of 0.03 and 3.5 μM, respectively. MLN9708 has shown antitumor activity both in cell-based assays and in xenograft models and has been examined in phase III clinical trials for potential antimyeloma activity.

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Suppliers and manufacturers

career henan chemical co
MLN9708
₹1.00 /1kg
MLN9708 CAS:1201902-80-8
AKASH PHARMA EXPORTS MSN LABORATORIES PRIVATE LTD SUN PHARMACEUTICAL INDUSTRIES LTD A.J Chemicals Pharmaffiliates Analytics and Synthetics P. Ltd
Alpha Biopharmaceuticals Co., Ltd
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
TargetMol Chemicals Inc.