CEP-18770
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- ₹0
- Product name: CEP-18770
- CAS: 847499-27-8
- MF: C21H28BN3O5
- MW: 413.28
- EINECS:
- MDL Number:MFCD18251439
- Synonyms:CEP-18770;[(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid;CIP 18770;CT 47098;Delanzomib;NPH 007098;CEP-18770 (DelanzoMib);DelanzoMib, Free Base, >99%
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Properties
Melting point :178-190°C (dec.)
Density :1.207
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.67±0.43(Predicted)
color :White to Off-White
Stability :Hygroscopic
Density :1.207
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.67±0.43(Predicted)
color :White to Off-White
Stability :Hygroscopic
Safety Information
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Description
Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity. Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis.Related product price
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Suppliers and manufacturers
Alpha Biopharmaceuticals Co., Ltd
Hangzhou FandaChem Co.,Ltd.
SIMAGCHEM CORP
WinWin Chemical CO., Limited
AFINE CHEMICALS LIMITED
Baoji Guokang Bio-Technology Co., Ltd.
Zhejiang J&C Biological Technology Co.,Limited
Nextpeptide Inc
Guangzhou TongYi biochemistry technology Co.,LTD