GDC-0623
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- Product name: GDC-0623
- CAS: 1168091-68-6
- MF: C16H14FIN4O3
- MW: 456.21
- EINECS:604-604-1
- MDL Number:MFCD25976760
- Synonyms:RG 7421;5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide;GDC-0623 (5-((2-Fluoro-4-Iodophenyl)amino)-N-(2-Hydroxyethoxy)imidazo[1,5-a]pyridine-6-Carboxamide);5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide RG 7421 GDC-0623;GDC-0623;MEK inhibitor 1;G-868;5-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE
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Properties
Density :1.81±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray
Safety Information
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Description
GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.Related product price
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