IMR-1
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- ₹0
- Product name: IMR-1
- CAS: 310456-65-6
- MF: C15H15NO5S2
- MW: 353.41
- EINECS:-0
- MDL Number:MFCD04141288
- Synonyms:IMR-1;[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]acetic acid ethyl ester;IMR-1, >98%;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester;IMR-1 >=98% (HPLC);2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl ester;IMR 1,IMR1,IMR-1,Notch,Inhibitor,inhibit;2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl este,IMR-1
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Properties
storage temp. :2-8°C(protect from light)
solubility :Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
form :solid
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
solubility :Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
form :solid
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
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Description
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1?IC50=26 μM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 μM (in vitro?assay). Binding of IMR-1 to NTC is non-covalent and reversible.1Related product price
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