Flavopiridol
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- ₹0
- Product name: Flavopiridol
- CAS: 146426-40-6
- MF: C21H20ClNO5
- MW: 401.84
- EINECS:
- MDL Number:MFCD20501884
- Synonyms:FLAVOPIRIDOL;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one;4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-;(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one;C077990;Hmr 1275;L 868275;L-868275
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Properties
Melting point :52.5 °C
Boiling point :603.6±55.0 °C(Predicted)
Density :1.448±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellow powder.
pka :6.16±0.40(Predicted)
color :Light yellow to yellow
InChIKey :BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES :C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference :146426-40-6(CAS DataBase Reference)
Boiling point :603.6±55.0 °C(Predicted)
Density :1.448±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellow powder.
pka :6.16±0.40(Predicted)
color :Light yellow to yellow
InChIKey :BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES :C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference :146426-40-6(CAS DataBase Reference)
Safety Information
Symbol(GHS): |
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Description
Flavopiridol is a synthetic flavone compound that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses expression of cyclin D1 and D3, interrupting the central role of Cdks in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9.Related product price
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Suppliers and manufacturers
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
AFINE CHEMICALS LIMITED
Dayang Chem (Hangzhou) Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem