Epacadostat (INCB024360)

CAS No.: 1204669-58-8

Chemical Name:: Epacadostat (INCB024360)

Synonyms: Epacadostat;CS-1617;INCB02436;INCN024360;(1204669-37-3);Epacadostat(INCB024360);INCB-24360(INCB-024360);Epacadostat(INCN024360);IDO inhibitor(INCB024360);INCB 024360 ， Epacadostat

CBNumber:: CB43038482

Molecular Formula:: C11H13BrFN7O4S

Molecular Weight:: 438.23

MOL File:: 1204669-58-8.mol

Modify Date:: 2023/6/8 9:02:45

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Epacadostat (INCB024360) Properties

Melting point	159 - 161°C
Boiling point	700.9±70.0 °C(Predicted)
Density	2.01±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml)
form	solid
pka	7.65±0.69(Predicted)
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Danger

Hazard statements

H332-H302-H312

Precautionary statements

P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501

NFPA 704

	0
3		0

Epacadostat (INCB024360) Chemical Properties,Uses,Production

Description

Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC₅₀ value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO). It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.

Uses

Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).

Epacadostat (INCB024360) Preparation Products And Raw materials

Raw materials

Preparation Products

Epacadostat (INCB024360) Suppliers

Global( 161)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	China	2141	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	CHINA	9427	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
BOC Sciences	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Baoji Guokang Healthchem co.,ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58

Epacadostat (INCB024360) Spectrum

Epacadostat (INCB024360)(1204669-58-8)¹HNMR

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(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide Epacadostat (INCB24360, INCB024360) N-(3-Bromo-4-fluoro-phenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine INCN024360 (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine Epacadostat(INCN024360) INCB-24360(INCB-024360) Epacadostat(INCB024360) [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]- IDO inhibitor(INCB024360) (1204669-37-3) INCB024360;INCB-024360;INCB 024360 CS-1617 INCB 024360 ， Epacadostat INCB02436 Epacadostat IDO inhibitor(INCB024360) Epacadostat (Z)-N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine 1204669-58-8