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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Epigenetic Reader Domain inhibitors >RVX-208

RVX-208

RVX-208 Structure
CAS No.
1044870-39-4
Chemical Name:
RVX-208
Synonyms
CS-686;CS-1815;RVX-208;RVX-000222;Apabetalone;RVX-208 USP/EP/BP;RVX-208(RVX000222);RVX-208(RVX 000222);Apabetalone-RVX-208;Apabetalone (RVX-08, RVX-000222)
CBNumber:
CB52640278
Molecular Formula:
C20H22N2O5
Molecular Weight:
370.4
MOL File:
1044870-39-4.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:50:00
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RVX-208 Properties

Boiling point 594.2±60.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. -20°C (des.)
solubility Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
form solid
pka 14.21±0.10(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H371
Precautionary statements  P260-P264-P270-P309+P311-P405-P501

RVX-208 Chemical Properties,Uses,Production

Description

The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.

Uses

RVX-208 is a selective antagonist of bromodomain and extra terminal (BET)’s bromodomains.

RVX-208 Preparation Products And Raw materials

Raw materials

Benzamide, 2-bromo-4,6-dimethoxy- Benzonitrile, 2-amino-4,6-dimethoxy- 2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE 3,5-diMethoxyaniline hydrochloride 3,5-Dimethyl-4-hydroxybenzaldehyde
2-Bromo-4,6-dimethoxybenzoic acid 4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde 2-aMino-4,6-diMethoxybenzaMide C17H28O3Si 4,6-DIMETHOXY-1H-INDOLE-2,3-DIONE
2-AMINO-4,6-DIMETHOXY-BENZOIC ACID 1-Bromo-3,5-dimethoxybenzene 3,5-Dimethoxybenzoic acid 3,5-Dihydroxybenzoic acid 3,5-Dimethoxyaniline
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Preparation Products

RVX-208 Suppliers

Global( 177)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
VCS Chem Tech Pvt Ltd +91-8008851342 +91-8008851342 Telangana, India 66 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. +8618068519287 China 833 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
VCS Chem Tech Pvt Ltd 58
A.J Chemicals 58
CHEMSWORTH 30
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

RVX-208 Spectrum

RVX-208(1044870-39-4)MSRVX-208(1044870-39-4)1HNMR

1044870-39-4(RVX-208)Related Search:

EPA Necrostatin-1 AICAR Nicardipine hydrochloride AZD6738
BLU 9931 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Enasidenib Epacadostat (INCB024360) Bortezomib
BroMosporine CPI-203 OTX015 I-BET-762 PFI-1
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2-(4-(2-hydroxyethoxy)-3,5-diMethylphenyl)-5,7-diMethoxyquinazolin-4(3H)-one RVX-000222 4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy- 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone RVX-208 RVX-208 Apabetalone Apabetalone-RVX-208 RVX-208(RVX 000222) RVX-208(RVX000222) CS-1815 APABETALONE; RVX-000222; RVX208; RVX 208; RVX000222; RVX 000222 CS-686 RVX-208 USP/EP/BP Apabetalone (RVX-08, RVX-000222) Apabetalone (RVX-208, RVX-000222) 2-(4-(2-Hydroxyethoxy)-2,6-dimethylphenyl)-6,8-dimethoxyquinazolin-4(3H)-one 1044870-39-4 Inhibitors API