ChemicalBook > Product Catalog >API >Circulatory system drugs >Angina Pectoris Drugs >Nicardipine hydrochloride
Nicardipine hydrochloride
- CAS No.
- 54527-84-3
- Chemical Name:
- Nicardipine hydrochloride
- Synonyms
- YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
- CBNumber:
- CB1244267
- Molecular Formula:
- C26H30ClN3O6
- Molecular Weight:
- 515.99
- MOL File:
- 54527-84-3.mol
- Modify Date:
- 2024/6/18 13:26:42
| Melting point | 176-1780C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: ~1 mg/mL |
| form | powder |
| color | yellow |
| Merck | 14,6495 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | AIKVCUNQWYTVTO-UHFFFAOYSA-N |
| CAS DataBase Reference | 54527-84-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US7972100 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399090 | |||||||||
| Toxicity | LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado) | |||||||||
| NFPA 704 |
|
Nicardipine hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N7510 | Nicardipine hydrochloride powder, ≥98% | 54527-84-3 | 1G | ₹12632.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2531 | Nicardipine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 54527-84-3 | 500MG | ₹22764.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7510 | Nicardipine hydrochloride powder, ≥98% | 54527-84-3 | 5G | ₹49513.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7510 | Nicardipine hydrochloride powder, ≥98% | 54527-84-3 | 10G | ₹79834.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0635 | Nicardipine Hydrochloride | 54527-84-3 | 5G | ₹8900 | 2022-05-26 | Buy |
Nicardipine hydrochloride Chemical Properties,Uses,Production
Description
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).
Chemical Properties
Yellow Solid
Uses
Dihydropyridine calcium channel blocker. Antianginal; antihypertensive
General Description
Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an
Nicardipine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 321)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Apothecon Pharmaceuticals Pvt., Ltd. | 91-2662-244212 | Gujarat, India | 9 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |
| GLAND PHARMA LTD | +91-40-30510999 | New Delhi, India | 52 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Related articles
- Introduction of Nicardipine hydrochloride
- Cardene (nicardipine hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker). Carde....
- Aug 28，2019
54527-84-3(Nicardipine hydrochloride)Related Search:
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methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride
Naratriptan HCl
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-[Methyl(phenylmethyl)amino]ethyl Ester Hydrochloride
Antagonyl
Barizin
Dacarel
Vasonas
YC-93
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
Vasonase
NICARDIPINE HYDROCHLORIDE (YC-93) CALCIU M CHANNEL ANTAG
NICARDIPINE HYDROCHLORIDE MM(CRM STANDARD)
YC-93, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
Aprovan
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl 5-[2-[Methyl(phenylMethyl)aMino]ethyl] ester, hydrochloride
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, hydrochloride (1:1)
5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-2-(
angioglebil
benzylmethylamino)ethylmethylester,monohydrochloride
bionicard
dafil
dagan
lincil
loxen
nicardil
perdipina
rs-69216
PERDIPINE
NICODEL
NICARDIPINE HCL
NICARDIPINE HYDROCHLORIDE
YC-93 HCL
YC-93 HYDROCHLORIDE
1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINE-DICARBOXYLIC ACID 3-METHYL ESTER 5-[2-(METHYL-(BENZYL)AMINO)ETHYL] ESTER HYDROCHLORIDE
1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2- [METHYL-(PHENYLMETHYL)AMINO]ETHYL ESTER HYDROCHLORIDE
1,4-DIHYDRO-2,6-DIMETHYL-4-[3-NITROPHENYL]METHYL-2-[METHYL(PHENYLMETHYL)AMINO]-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
Nicardipine Hydrochloride, 99.0+ % (HPLC)
NicardipineHydrochloride>
Nicardipine for system suitability
Nicardipine hydrochloride USP/EP/BP
3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Antagonil, Dagan, Flusemide)
Nicardipine HCl (RS69216
Nicardipine 13CD3 Hydrochloride
Nicardipine HydrochlorideQ: What is
Nicardipine Hydrochloride Q: What is the CAS Number of
Nicardipine Hydrochloride Q: What is the storage condition of
Nicardipine Hydrochloride Q: What are the applications of
Nicardipine Hydrochloride
Nicardipine Hydrochloride (1463224)
13C,2H3]-Nicardipine Hydrochloride
Nicardipine Hydrochloride, ≥ 98.0%
54527-84-3
5427-84-3
C26H29N3O6HCl
C26H30ClN3O6
C25H28ClN3O6
C26H29N3O6ClH
Inhibitors and Activators
Ion Channels
Voltage-gated Ion Channels