GSK 525762A
- CAS No.
- 1260907-17-2
- Chemical Name:
- GSK 525762A
- Synonyms
- I-BET-762;GSK525762;Molibresib;GSK 525762A;IBET762(GSK525762A);Molibresib (I-BET762;GSK525762 (I-BET-762);GSK 525762A USP/EP/BP;GSK 525762A (I-BET-762);Molibresib (GSK 525762A)
- CBNumber:
- CB42627926
- Molecular Formula:
- C22H22ClN5O2
- Molecular Weight:
- 423.9
- MOL File:
- 1260907-17-2.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | >132°C (dec.) |
|---|---|
| Density | 1.35 |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) |
| pka | 15.71±0.46(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +80 to +90°, c = 0.3 in methanol |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GSK 525762A price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1272 | I-BET762 ≥98% (HPLC) | 1260907-17-2 | 5MG | ₹13423 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1272 | I-BET762 ≥98% (HPLC) | 1260907-17-2 | 25MG | ₹54547.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 401010 | I-BET - CAS 1260907-17-2 - Calbiochem A cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain) family members BRD2 (1-473) | 1260907-17-2 | 5MG | ₹9380 | 2022-06-14 | Buy |
GSK 525762A Chemical Properties,Uses,Production
Description
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-
Uses
GSK 525762A, is a BET Bromodomain Inhibitor, which is now in clinical development. BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.
Biochem/physiol Actions
I-BET762 possesses anti-inflammatory property by controlling the pro-inflammatory gene expression. I-BET762 hinders the MYC (proto-oncogene) expression in cellular models. This action of I-BET762 might serve as an effective therapy in treating prostate cancer.
GSK 525762A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aravali Pharma And Lifesciences | +91-9350857917 +91-9810502945 | New Delhi, India | 119 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |