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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Epigenetic Reader Domain inhibitors >OTX015

OTX015

OTX015 Structure
CAS No.
202590-98-5
Chemical Name:
OTX015
Synonyms
MK8628;OTX015;OTX 015;OTX-015;MK 8628;MK-8628;CS-1013;OXT-015;Birabresib;OTX015(OTX-015)
CBNumber:
CB42666673
Molecular Formula:
C25H22ClN5O2S
Molecular Weight:
491.99
MOL File:
202590-98-5.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
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OTX015 Properties

Melting point 220 °C
Density 1.45±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility ≥24.6 mg/mL in DMSO; insoluble in H2O; ≥106 mg/mL in EtOH with gentle warming
pka 10.05±0.26(Predicted)
form powder
color white to light brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934.99.3900

OTX015 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1605 OTX015 ≥98% (HPLC) 202590-98-5 5MG ₹24735.13 2022-06-14 Buy
Sigma-Aldrich(India) SML1605 OTX015 ≥98% (HPLC) 202590-98-5 25MG ₹96591.48 2022-06-14 Buy
TCI Chemicals (India) O0482 OTX 015 202590-98-5 10MG ₹8400 2022-05-26 Buy
TCI Chemicals (India) O0482 OTX 015 202590-98-5 50MG ₹33000 2022-05-26 Buy
Product number Packaging Price Buy
SML1605 5MG ₹24735.13 Buy
SML1605 25MG ₹96591.48 Buy
O0482 10MG ₹8400 Buy
O0482 50MG ₹33000 Buy

OTX015 Chemical Properties,Uses,Production

Description

The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM). It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis. At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.

Uses

(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide is an orally bioavailable, inhibitor of BRD2, BRD3, and BRD4 to AcH4 and shows anti-tumor activity in vitro and in vivo tumor models.

Biochem/physiol Actions

It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.

OTX015 Preparation Products And Raw materials

Raw materials

Preparation Products

OTX015 Suppliers

Global( 165)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2141 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Shanghai Daeyeon Chemicals Co., Ltd 021-64478606 +8615900664856 China 2062 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
Wuhan Fortuna Chemical Co., Ltd +86-027-59207850 China 6000 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Supplier Advantage
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
Zhejiang ZETian Fine Chemicals Co. LTD 58
BOC Sciences 58
career henan chemical co 58
Shanghai Daeyeon Chemicals Co., Ltd 58
Dideu Industries Group Limited 58
Wuhan Fortuna Chemical Co., Ltd 58
Zhejiang J&C Biological Technology Co.,Limited 58

OTX015 Spectrum

OTX015(202590-98-5)1HNMR

202590-98-5(OTX015)Related Search:

I-BET151 (GSK1210151A) (+)-JQ1 RVX-208 CPI-203 I-BET-762
PFI-1
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OTX015(OTX-015) 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)- MK 8628 MK8628 MK-8628 OTX015;OTX 015;OTX-015 2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide OTX 015 OTX015 OTX-015 (S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide (6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide (S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide OTX-015 CS-1013 OXT-015 OTX 015; OTX015;MK-8628; MK 8628; MK8628;OTX-015 Birabresib OTX-015 (Birabresib) OTX015(MK-8628,Birabresib) OTX015; OTX-015; OTX 015; MK-8628; MK 8628; MK8628; BIRABRESIB. Birabresib(OTX-015) OTX015 USP/EP/BP Venadaparib Impurity 93 202590-98-5 2202590-98-5 Inhibitors