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RVX-208

RVX-208 Structure
RVX-208 structure
CAS No.
1044870-39-4
Chemical Name:
RVX-208
Synonyms
CS-686;CS-1815;RVX-208;RVX-000222;Apabetalone;RVX-208 USP/EP/BP;RVX-208(RVX000222);RVX-208(RVX 000222);Apabetalone-RVX-208;Apabetalone (RVX-08, RVX-000222)
CBNumber:
CB52640278
Molecular Formula:
C20H22N2O5
Molecular Weight:
370.4
MDL Number:
MFCD18633270
MOL File:
1044870-39-4.mol
MSDS File:
SDS
Last updated:2024-11-06 15:28:16
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RVX-208 Properties

Boiling point 594.2±60.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. -20°C (des.)
solubility Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
form solid
pka 14.21±0.10(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
FDA UNII 8R4A7GDZ1D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H371
Precautionary statements  P260-P264-P270-P309+P311-P405-P501

RVX-208 price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16424 RVX-208 ≥98% 1044870-39-4 1mg $44 2024-03-01 Buy
Cayman Chemical 16424 RVX-208 ≥98% 1044870-39-4 5mg $109 2024-03-01 Buy
Cayman Chemical 16424 RVX-208 ≥98% 1044870-39-4 10mg $193 2024-03-01 Buy
Cayman Chemical 16424 RVX-208 ≥98% 1044870-39-4 25mg $404 2024-03-01 Buy
TRC R800000 RVX208 1044870-39-4 25mg $330 2021-12-16 Buy
Product number Packaging Price Buy
16424 1mg $44 Buy
16424 5mg $109 Buy
16424 10mg $193 Buy
16424 25mg $404 Buy
R800000 25mg $330 Buy

RVX-208 Chemical Properties,Uses,Production

Description

The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.

Uses

RVX-208 is a selective antagonist of bromodomain and extra terminal (BET)’s bromodomains.

target

BD2

References

1) Picaud?et al. (2013),?RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain; Proc. Natl. Acad. Sci. USA,?110?19754 2) McLure?et al. (2013),?RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist; PLoS One,?8e83190 3) Bailey?et al. (2010),?RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; J. Am. Coll. Cardiol.,?55?2580 4) Jahagirdar?et al. (2014),?A novel BET bromodomain inhibitor, RVX-208 shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice; Atherosclerosis,?236?91

RVX-208 synthesis

1039948-89-4
63920-73-0
1044870-39-4
Synthesis of RVX-208 from 4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde and 2-aMino-4,6-diMethoxybenzaMide

RVX-208 Preparation Products And Raw materials

Raw materials

Benzamide, 2-bromo-4,6-dimethoxy- Benzonitrile, 2-amino-4,6-dimethoxy- 2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE 3,5-diMethoxyaniline hydrochloride 3,5-Dimethyl-4-hydroxybenzaldehyde
2-Bromo-4,6-dimethoxybenzoic acid 4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde 2-aMino-4,6-diMethoxybenzaMide C17H28O3Si 4,6-DIMETHOXY-1H-INDOLE-2,3-DIONE
2-AMINO-4,6-DIMETHOXY-BENZOIC ACID 1-Bromo-3,5-dimethoxybenzene 3,5-Dimethoxybenzoic acid 3,5-Dihydroxybenzoic acid 3,5-Dimethoxyaniline

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Preparation Products

RVX-208 Suppliers

Global( 180)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 		+8615995072465 sales@xuanmingchem.com China 914 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58

View Lastest Price from RVX-208 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Apabetalone pictures 2024-11-06 Apabetalone
1044870-39-4
 US $39.00-119.00 / mg ≥98% 10g TargetMol Chemicals Inc.
RVX-208 pictures 2019-12-23 RVX-208
1044870-39-4
 US $1.00 / g 100g 99% G/KG/T Career Henan Chemical Co
  • Apabetalone pictures
  • Apabetalone
    1044870-39-4
  • US $39.00-119.00 / mg
  • ≥98%
  • TargetMol Chemicals Inc.
  • RVX-208 pictures
  • RVX-208
    1044870-39-4
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

RVX-208 Spectrum

RVX-208(1044870-39-4)MSRVX-208(1044870-39-4)1HNMR

1044870-39-4(RVX-208)Related Search:

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BroMosporine CPI-203 OTX015 I-BET-762 PFI-1

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2-(4-(2-hydroxyethoxy)-3,5-diMethylphenyl)-5,7-diMethoxyquinazolin-4(3H)-one RVX-000222 4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy- 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone RVX-208 RVX-208 Apabetalone Apabetalone-RVX-208 RVX-208(RVX 000222) RVX-208(RVX000222) CS-1815 APABETALONE; RVX-000222; RVX208; RVX 208; RVX000222; RVX 000222 CS-686 RVX-208 USP/EP/BP Apabetalone (RVX-08, RVX-000222) Apabetalone (RVX-208, RVX-000222) 2-(4-(2-Hydroxyethoxy)-2,6-dimethylphenyl)-6,8-dimethoxyquinazolin-4(3H)-one 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4aH-quinazolin-4-one 1044870-39-4 Inhibitors API