Necrostatin-1
- CAS No.
- 4311-88-0
- Chemical Name:
- Necrostatin-1
- Synonyms
- Nec 1;CS-959;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;IFLAB-BB F0911-6127;Necrostatin-1, >=98%;Necrostatin-1 (Nec-1);Necrostatin-1 USP/EP/BP;Ceftobiprole Impurity 24;NECROSTATIN1; NECROSTATIN 1
- CBNumber:
- CB6776886
- Molecular Formula:
- C13H13N3OS
- Molecular Weight:
- 259.33
- MOL File:
- 4311-88-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 151℃ |
|---|---|
| Boiling point | 441.9±37.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| Flash point | 93.3℃ |
| storage temp. | -20°C |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 9.46±0.40(Predicted) |
| color | Pale yellow |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Necrostatin-1 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N9037 | Necrostatin-1 ≥98% (HPLC) | 4311-88-0 | 10MG | ₹16562.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N9037 | Necrostatin-1 ≥98% (HPLC) | 4311-88-0 | 25MG | ₹36393.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 480065 | Necrostatin-1 - CAS 4311-88-0 - Calbiochem Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC?? = 494 nM in FADD-deficient Jurkat cells treated | 4311-88-0 | 5MG | ₹17579.99 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N1174 | Necrostatin-1 | 4311-88-0 | 100MG | ₹19800 | 2022-05-26 | Buy |
| ALFA India | ALF-J65341-FPL | Necrostatin-1 | 4311-88-0 | 20mg | ₹11098 | 2022-05-26 | Buy |
Necrostatin-1 Chemical Properties,Uses,Production
Uses
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Biological Activity
ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
Biochem/physiol Actions
Necrostatin-1(Nec-1) might exhibit therapeutic benefit against patients with traumatic brain injury (TBI). In addition, it might also be used to treat other acute central nervous system (CNS) disorders that feature necroptosis as a mode of cell death. It is extensively used to study the effect of receptor-interacting protein kinase 1 (RIPK1) on cell death and inflammation in experimental disease models. Nec‐1 protects hippocampal (HT‐22) cells from glutamate‐induced oxytosis via increasing cellular glutathione (GSH) levels, decreasing reactive oxygen species production, inhibiting the nuclear translocation of apoptosis‐inducing factor and B-cell lymphoma 2 (Bcl‐2) /adenovirus E1B 19kDa‐interacting protein 3‐related pathways.
Necrostatin-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| BOC Sciences | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |