Necrostatin-1
Necrostatin-1
- CAS:
- 4311-88-0
- MF:
- C13H13N3OS
- MW:
- 259.33
Suppliers by country/region
Company Type
Properties
- Melting point:
- 151℃
- Boiling point:
- 441.9±37.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 93.3℃
- storage temp.
- -20°C
- solubility
- DMSO: >10 mg/mL
- pka
- 9.46±0.40(Predicted)
- form
- solid
- color
- Pale yellow
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H317
- Precautionary statements
- P280
- Risk Statements
- 36/37/39
- Safety Statements
- 36/37/39
- WGK Germany
- 3
- HS Code
- 29339900
Use
Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.
1 India supplier list of "Necrostatin-1"
- Product Name:Necrostatin-1-CAS4311-88-0-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:480065 | Purity:Necrostatin-1,CAS4311-88-0,isacell-permeable,potent,andselectiveblockerofnecropt
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Necrostatin-1 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.167923
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Necrostatin-1,
- Products Intro:Brand:thermofisher.in | Product Number:ALF-J65341-FPL
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Necrostatin-1
- Products Intro:Brand:clearsynth | Product Number:CS-T-59203
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Necrostatin1
- Products Intro:Brand:ajchemicals | Product Number:JDH-34858 | Purity:98+%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Necrostatin-1
- Products Intro:Brand:tcichemicals | Product Number:N1174
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Necrostatin-1
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
$5.00/ 5KG
- Product Name:Necrostatin-1
- Products Intro:Purity: 99% | Package: 5KG;5USD
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Necrostatin-1
- Products Intro:Purity: >98% | Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for Necrostatin-1.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Necrostatin-1
- Products Intro:Purity: 98% | Package: Package as requetsed
- Company Type: Trader
- Country/Region: CHINA