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ChemicalBook > Product Catalog >Biochemical Engineering >Nucleoside drugs >Nucleotides and their analogs >3-METHYLADENINE

3-METHYLADENINE

3-METHYLADENINE Structure
CAS No.
5142-23-4
Chemical Name:
3-METHYLADENINE
Synonyms
109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
CBNumber:
CB9307216
Molecular Formula:
C6H7N5
Molecular Weight:
149.15
MOL File:
5142-23-4.mol
Modify Date:
2024/4/28 19:50:54
Request For Quotation

3-METHYLADENINE Properties

Melting point ~300 °C (dec.)(lit.)
Boiling point 240℃
Density 1.60
refractive index 1.8070 (estimate)
Flash point 99℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
pka 6.77±0.20(Predicted)
form Powder
color White
BRN 146087
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c
Hazard Codes  Xn
Risk Statements  22
Safety Statements  24/25
WGK Germany  3
RTECS  AU6520000
HS Code  29335990
NFPA 704
0
2 0

3-METHYLADENINE price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M9281 3-Methyladenine autophagy inhibitor 5142-23-4 100MG ₹16454 2022-06-14 Buy
Sigma-Aldrich(India) M9281 3-Methyladenine autophagy inhibitor 5142-23-4 500MG ₹64960.83 2022-06-14 Buy
Sigma-Aldrich 189490 Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker. Acts as an inhibitor of III PI3-Kinase. 5142-23-4 50MG ₹13520 2022-06-14 Buy
Sigma-Aldrich(India) 189490 Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker. Acts as an inhibitor of III PI3-Kinase. 5142-23-4 50MG ₹13520 2022-06-14 Buy
Sigma-Aldrich 189490 Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker. Acts as an inhibitor of III PI3-Kinase. 5142-23-4 100MG ₹16920 2022-06-14 Buy
Product number Packaging Price Buy
M9281 100MG ₹16454 Buy
M9281 500MG ₹64960.83 Buy
189490 50MG ₹13520 Buy
189490 50MG ₹13520 Buy
189490 100MG ₹16920 Buy

3-METHYLADENINE Chemical Properties,Uses,Production

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

Chemical Properties

White powder

Uses

3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

Definition

ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.

General Description

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

3-METHYLADENINE Preparation Products And Raw materials

Raw materials

Adenine Toluene Nickel Monoperoxyphthalic acid magnesium salt hexahydrate Benzyl bromide
N,N-Dimethylacetamide Sulfuric acid Dimethyl sulfate Adenosine, 2'-deoxy-,1-oxide (7CI,8CI,9CI) 3-Methyl Adenosine p-Toluenesulfonate Salt
Adenine-7-oxide 9-Methyladenine Iodomethane
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Preparation Products

1-METHYLADENINE

3-METHYLADENINE Suppliers

Global( 272)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10991 58 Inquiry
Henan Fengda Chemical Co., Ltd +86-371-86557731 +86-13613820652 China 20290 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29899 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8818 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Otto Chemie Pvt. Ltd. 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
Henan Fengda Chemical Co., Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Hebei Guanlang Biotechnology Co., Ltd. 58
BOC Sciences 58

3-METHYLADENINE Spectrum

3-METHYLADENINE(5142-23-4)MS3-METHYLADENINE(5142-23-4)1HNMR3-METHYLADENINE(5142-23-4)IR13-METHYLADENINE(5142-23-4)Raman

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3H-Purin-6-amine, 3-methyl- 3-methyl-3h-purin-6-amin 3-Methyl-3H-purin-6-amine 3-methyl-adenin Adenine, 3-methyl- 3-METHYLADENINE 3-methyl-3H-adenine 6-AMINO-3-METHYLPURINE 3-Methyladenine, 90+%, pure 3-Methyladenine, pure 3-Methyl-6-amino-3H-purine 3-Methyladenine6-Amino-3-methylpurine 3-Methyladenine, pure, 90+% 3-Methyl-6-aminopurine N3-Methyladenine NSC 66389 3-MA (3-Methyl adenine) 3-methyladenine,3MA NSC 66389,3-MA 3-Methyladenine, GC 90+% NSC 66389,3-M 6-Amino-3-methylpurine 3-Methyladenine Autophagy Inhibitor 3-Methyladenine, >=98% Autophagy Inhibitor, 3-MA Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem 109723 3-methylpurin-6-amine Methyladenine Methyladenine NSC-63889 3-METHYLADENINE USP/EP/BP N3-Methyladenine/NSC 66389 3-Methyl-6-am 5142-23-4 Building Blocks Biochemicals and Reagents BioChemical Heterocyclic Building Blocks Purines Nucleoside Analogs Nucleosides, Nucleotides, Oligonucleotides Akt mTOR PI3K Amines Bases & Related Reagents Heterocycles Inhibitors Nucleotides