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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >Caspase inhibitors >Z-VAD-FMK

Z-VAD-FMK

Z-VAD-FMK Structure
CAS No.
187389-52-2
Chemical Name:
Z-VAD-FMK
Synonyms
CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
CBNumber:
CB0203438
Molecular Formula:
C22H30FN3O7
Molecular Weight:
467.49
MOL File:
Mol file
MSDS File:
SDS
Modify Date:
2023/9/5 11:06:02
Request For Quotation

Z-VAD-FMK Properties

Melting point >190°C (dec.)
Boiling point 732.4±60.0 °C(Predicted)
Density 1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point 396.7℃
storage temp. -20°C
solubility DMSO: 20 mg/mL
form powder
pka 11.05±0.46(Predicted)
color white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey MIFGOLAMNLSLGH-QOKNQOGYSA-N
SMILES C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(OC)=O)C(=O)CF
CAS DataBase Reference 187389-52-2

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  22-24/25
WGK Germany  3
HS Code  29145090

Z-VAD-FMK price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) V116 Z-VAD-FMK solid 187389-52-2 2MG ₹87628.38 2022-06-14 Buy
Sigma-Aldrich(India) 627610 Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. 187389-52-2 1MG ₹32810 2022-06-14 Buy
Sigma-Aldrich(India) SAB2501669 Anti-CASP3 antibody produced in goat affinity isolated antibody, buffered aqueous solution 187389-52-2 100μG ₹53135.7 2022-06-14 Buy
Sigma-Aldrich(India) 627610 Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. 187389-52-2 5MG ₹57700 2022-06-14 Buy
Product number Packaging Price Buy
V116 2MG ₹87628.38 Buy
627610 1MG ₹32810 Buy
SAB2501669 100μG ₹53135.7 Buy
627610 5MG ₹57700 Buy

Z-VAD-FMK Chemical Properties,Uses,Production

Uses

Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.

General Description

A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

Z-VAD-FMK Suppliers

Global( 210)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10311 58 Inquiry
Shanghai Longyu Biotechnology Co., Ltd. +8619521488211 China 2534 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
BOC Sciences 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Shenzhen Nexconn Pharmatechs Ltd 58
Shanghai Longyu Biotechnology Co., Ltd. 58
Chongqing Chemdad Co., Ltd 58
Dideu Industries Group Limited 58

Z-VAD-FMK Spectrum

Z-VAD-FMK(187389-52-2)1HNMR

187389-52-2(Z-VAD-FMK)Related Search:

Z-FA-FMK Z-DEVD-FMK Z-Vad-fmk, non-methylated 3-METHYLADENINE MK-2206 2HCl
Necrostatin-1 MG-132 LY 294002 HYDROCHLORIDE (2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoic acid PAC1
AC-DEVD-CHO AC-VDVAD-PNA Z-PHE-DL-ALA-FLUOROMETHYLKETONE Z-VAL-ALA-OH Z-VAL-TRP-OH
CBZ-L-VALINE METHYL ESTER Z-VAL-VAL-ARG-AMC Z-VAL-VAL-OH
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Z-VADC(OME)-FMK methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-phenylmethoxycarbonylamino-butanoyl]amino]propanoyl]amino]-4-oxo-pentanoate N-BENZYLOXYCARBONYL-VAL-ALA-ASP FLUOROMETHYL KETONE Z-VAD-FLUOROMETHYLKETONE Z-VAD-FMK Z-VAD-FMK, METHYL ESTER Z-VAD(OME)-FLUOROMETHYLKETONE L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide z-vad -fmk Anti-CASP3 antibody produced in goat caspase 3, apoptosis-related cysteine peptidase caspase 3, apoptosis-related cysteine protease HGNC:1504 Z-VAD-FMK, >=98% Z-VAD(OME)-FMK Z-VAL-ALA-ASP-FLUOROMETHYLKETONE Z-VAL-ALA-ASP-FMK Z-VAL-ALA-ASP(OCH3)-FLUOROMETHYLKETONE Z-VAL-ALA-ASP(OME)-CH2F Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-VAL-ALA-ASP-(OME)-FMK Z-VAL-ALA-DL-ASP-FLUOROMETHYLKETONE Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE Z-VA(OME)D-FMK N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone BENZYLOXYCARBONYL-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE CARBOBENZOXY-VALYL-ALANYL-ASPARTYL-[O-METHYL]-FLUOROMETHYLKETONE CASPASE-1, INHIBITOR CASPASE-1 INHIBITOR VI (FLUOROMETHYLKETONE) CASPASE INHIBITOR I CASPASE INHIBITOR VI Z-VAD-FMK, Non-methylated PN: WO2005039629 PAGE: 18 claimed protein Z-VAD-FMK (Cell perMeable) 3: PN: WO0158526 SEQID: 3 claimed sequence N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide Z-VAD-FMK, 98%, an irreversible pan-caspase inhibitor Z-VAD(OME)-FMK;Z-VAL-ALA-ASP(OME)-FMK Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONEZ-Val-Ala-DL-Asp-fluoroMethylketone CS-2005 CS-1507 Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) Methyl (S)-3-[(S)-2-[(S)-2-(Cbz-amino)-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate (5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Z-VAD-FMK USP/EP/BP Caspase 3/7 Activity Assay Kit Methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Inhibitor,ZVAD(OMe)FMK,inhibit,Caspase,Z VAD(OMe) FMK Z-Val-Ala-Dl-Asp(Ome)-FMK 187389-52-2 67465-36-3 C22H30FN3O7 C21H28N3O7F C22H30N3O7F BioChemical Apoptosis and Cell Cycle Cell Biology Cell Signaling and Neuroscience