Z-VAD-FMK
![Z-VAD-FMK Structure](StructureFile/ChemBookStructure6/GIF/CB0203438.gif)
- CAS No.
- 187389-52-2
- Chemical Name:
- Z-VAD-FMK
- Synonyms
- CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
- CBNumber:
- CB0203438
- Molecular Formula:
- C22H30FN3O7
- Molecular Weight:
- 467.49
- MOL File:
- Mol file
- MSDS File:
- SDS
- Modify Date:
- 2023/9/5 11:06:02
Melting point | >190°C (dec.) |
---|---|
Boiling point | 732.4±60.0 °C(Predicted) |
Density | 1.214±0.06 g/cm3 (20 ºC 760 Torr) |
Flash point | 396.7℃ |
storage temp. | -20°C |
solubility | DMSO: 20 mg/mL |
form | powder |
pka | 11.05±0.46(Predicted) |
color | white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
InChIKey | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
SMILES | C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(OC)=O)C(=O)CF |
CAS DataBase Reference | 187389-52-2 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
HS Code | 29145090 |
Z-VAD-FMK price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | V116 | Z-VAD-FMK solid | 187389-52-2 | 2MG | ₹87628.38 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 627610 | Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. | 187389-52-2 | 1MG | ₹32810 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SAB2501669 | Anti-CASP3 antibody produced in goat affinity isolated antibody, buffered aqueous solution | 187389-52-2 | 100μG | ₹53135.7 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 627610 | Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. | 187389-52-2 | 5MG | ₹57700 | 2022-06-14 | Buy |
Z-VAD-FMK Chemical Properties,Uses,Production
Uses
Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.
General Description
A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.
Biological Activity
Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .
Enzyme inhibitor
This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.
Z-VAD-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | China | 2534 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
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