Simvastatin
- CAS No.
- 79902-63-9
- Chemical Name:
- Simvastatin
- Synonyms
- ZOCOR;mk-0733;2,2-Dimethylbutanoic acid (1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl ester;Denan;Eucor;Lipex;MK-733;Rechol;Simcor;Zocord
- CBNumber:
- CB9716324
- Molecular Formula:
- C25H38O5
- Molecular Weight:
- 418.57
- MOL File:
- 79902-63-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/8 14:48:35
| Melting point | 127-132 °C (lit.) |
|---|---|
| alpha | D25 +292° (c = 0.5% in acetonitrile) |
| Boiling point | 564.9±50.0 °C(Predicted) |
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 13.49±0.40(Predicted) |
| form | solid |
| color | white |
| optical activity | [α]/D +275±25°, c = 1 in acetonitrile |
| Merck | 14,8539 |
| BCS Class | 2 |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| CAS DataBase Reference | 79902-63-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Simvastatin(79902-63-9) |
| EPA Substance Registry System | Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361d | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | EK7798000 | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
Simvastatin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S6196 | Simvastatin ≥97% (HPLC), solid | 79902-63-9 | 5MG | ₹4189.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S6196 | Simvastatin ≥97% (HPLC), solid | 79902-63-9 | 25MG | ₹18597.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1438 | Simvastatin Pharmaceutical Secondary Standard; Certified Reference Material | 79902-63-9 | 1G | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 567020 | Simvastatin - CAS 79902-63-9 - Calbiochem A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. | 79902-63-9 | 50MG | ₹31020 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 38956 | Simvastatin analytical standard | 79902-63-9 | 10MG | ₹12037.4 | 2022-06-14 | Buy |
Simvastatin Chemical Properties,Uses,Production
Description
Simvastatin is an once-daily hypolipemic, an analog of lovastatin indicated for the treatment of atherosclerosis. In patients with Type IN or IIB hypercholesterolemia, simvastatin reportedly produces significant reductions in total serum cholesterol, LDL, mglycerides and apolipoprotein-B, while HDL and apolipoprotein-A levels are increased.
Chemical Properties
White Powder
Uses
Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
Definition
ChEBI: A carbobicyclic compound that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
General Description
Simvastatin, 2,2-dimethyl butanoic acid,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2-pyran-2-yl)ethyl]-1-naphthalenyl ester(Zocor), is an analog of lovastatin. These two drugs havemany similar properties. Both drugs, in the prodrug form,reach the liver unchanged after oral administration, wherethey undergo extensive metabolism to several open-ring hydroxyacids, including the active -hydroxy acids. They arealso highly bound to plasma proteins. These actions makethe bioavailability of simvastatin rather poor but better thanthat of lovastatin, which has been estimated to be 5%.
Biological Activity
HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity.
Simvastatin Preparation Products And Raw materials
Raw materials
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Global( 737)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Dodhia Group | +91-9619867345 +91-9619867345 | Mumbai, India | 129 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Krebs Biochemicals And Industries Limited | +91-4066808040 +91-4066808040 | Telangana, India | 3 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Dinakara Life Sciences Private Limited | +91-4048553395 +91-8668856516 | Telangana, India | 25 | 58 | Inquiry |
| Mulji Mehta Pharma | 08048372632Ext 619 | Mumbai, India | 134 | 58 | Inquiry |
79902-63-9(Simvastatin)Related Search:
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(1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste
7-beta,8-beta(2s*,4s*),8a-beta))-alph
[1S-[1α，3α，7β，8β(2S^<*>^，4S^<*>^)，8αβ]-2，2-Dimethylbutanoic acid 1，2，3，7，8，8α-hexahydro-3，7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-y1)ethyl]-1-naphthyl ester
Lodaiès
[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoat
Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro- 4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha,3-alpha,7- beta,8-beta(2S*,4S*),8a-beta))
[8-[2-(4-Hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate
2,2-Dimethylbutyric acid (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalene-1-yl ester
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethylbutanoate
LIPONORM
MK-733
SIMVASTATIN
SYNVINOLIN
(1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYLY-2,2-DIMETHYL BUTANOATE
2,2-DIMETHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
2,2-DIMETHYLBUTANOIC ACID 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-TETRAHYDRO-4-HYDROXY-2-OXO-2H-PYRAN-YL]-1-NAPHTHALENYL ESTER
Simvastatin (200 mg)
Simvastatin (200 mg)I0D3820.994mg/mg(ai)
SiMvastatin (COS)
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-diMethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-diMethylbutanoate
6'-exoMethylene SiMvastatin, Acid SodiuM Salt
SiMvastatin (EP/BP)
SiMvastatin API
SIMVASTATIN USP24
Simvastatin USP23,24
SimvastatinC25H3805
SimvastatineUsp25
butanoicacid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahy
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
2,2-Dimethlbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethl-8-[2-tetrahyddro-4-hydroxy-2-oxo-2H-pydran-yl]-1-naphthalenyl ester
4-(tert-butyl-dimethyl-silanyloxy)-6-(2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro
Zocor, MK-733, Liponorm
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester
SIMVASTATIN,USP
2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (9CI)
Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1a,3a,7b,8b(2S*,4S*),8ab]]-
Cholestat
Denan
Eucor
Kolestevan
Lipex
Lipinorm
Lipovas
Lodales
Modutrol
Nor-Vastina
Rechol
Simcor
Simovil
Simvotin
Sinvacor
Sinvascor
Sivastin
Valemia
Velostatin
Zocord
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-diMethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-diMethylbutanoate