ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >Tazemetostat (EPZ-6438)

Tazemetostat (EPZ-6438)

CAS No.: 1403254-99-8

Chemical Name:: Tazemetostat (EPZ-6438)

Synonyms: Tazemetostat;EPZ-6438;E-7438;CS-971;CPDB1064;EPZ-7438;EPZ-6438(E7438);E7438, Tazemetostat;Tazemetostat EPZ-6438;Henagliflozin Proline

CBNumber:: CB82655404

Molecular Formula:: C34H44N4O4

Molecular Weight:: 572.74

MOL File:: 1403254-99-8.mol

Modify Date:: 2024/3/25 11:48:53

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Tazemetostat (EPZ-6438) Properties

Melting point	>162°C (dec.)
Boiling point	750.8±60.0 °C(Predicted)
Density	1.163±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml).
pka	11.92±0.10(Predicted)
form	solid
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

Tazemetostat (EPZ-6438) Chemical Properties,Uses,Production

Uses

EPZ 6438 is a potent and selective inhibitor of EZH2.

Biological Activity

Tazemetostat (EPZ-6438) is a potent, and selective EZH2 inhibitor with K i and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMT.

target

EZH2(Cell-free assay)

Tazemetostat (EPZ-6438) Preparation Products And Raw materials

Raw materials

5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide Benzoic acid, 5-broMo-2-Methyl-3-[(tetrahydro-2H-pyran-4-yl)aMino]-, Methyl ester 3-(aMinoMethyl)-4,6-diMethyl-1,2-dihydropyridin-2-one hydrochloride Methyl 3-AMino-5-broMo-2-Methylbenzoate 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE Benzoic acid, 5-broMo-3-[ethyl(tetrahydro-2H-pyran-4-yl)aMino]-2-Methyl-, Methyl ester 5-BROMO-2-METHYL-3-NITROBENZOIC ACID Benzoic acid, 5-broMo-3-[ethyl(tetrahydro-2H-pyran-4-yl)aMino]-2-Methyl-

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Preparation Products

Tazemetostat (EPZ-6438) Suppliers

Global( 191)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12447	58	Inquiry
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	China	973	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
Hebei Mojin Biotechnology Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58

Tazemetostat (EPZ-6438) Spectrum

Tazemetostat (EPZ-6438)(1403254-99-8)MS

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E-7438 EPZ-7438 N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide [1,1'-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)- N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide EPZ6438 Henagliflozin Proline Tazemetostat EPZ-6438 EPZ-6438(E7438) N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino CPDB1064 EPZ6438(Tazemetostat) N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide E7438, Tazemetostat N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)biphenyl-3-carboxamide EPZ6438;EPZ 6438;E-7438;TAZEMETOSTAT CS-971 E7438,EPZ6438, EPZ-6438 EPZ6438; EPZ 6438; E-7438 [1,1'-Biphenyl]-3-carboxamide Tazemetostat (EPZ-6438) USP/EP/BP N-[(4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-[ethyl(tetrahydropyran-4-yl)amino]-4-methyl-4'-(morpholinomethyl)biphenyl-3-carboxamide EPZ-6438 Tazemetostat N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide EPZ6438 Tazemetostat EPZ-6438 EPZ 6438,epigenetic,inhibit,E 7438,Tazemetostat,Histone Methyltransferase,EPZ-6438,Inhibitor,E7438,EZH1,cancer,EZH2,PRC2 N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide 1403254-99-8 C34H44N4O4 Inhibitors