ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >Tazemetostat (EPZ-6438)
Tazemetostat (EPZ-6438)
![Tazemetostat (EPZ-6438) Structure](CAS/20150408/GIF/1403254-99-8.gif)
- CAS No.
- 1403254-99-8
- Chemical Name:
- Tazemetostat (EPZ-6438)
- Synonyms
- Tazemetostat;EPZ-6438;E-7438;CS-971;CPDB1064;EPZ-7438;EPZ-6438(E7438);E7438, Tazemetostat;Tazemetostat EPZ-6438;Henagliflozin Proline
- CBNumber:
- CB82655404
- Molecular Formula:
- C34H44N4O4
- Molecular Weight:
- 572.74
- MOL File:
- 1403254-99-8.mol
- Modify Date:
- 2024/3/25 11:48:53
Melting point | >162°C (dec.) |
---|---|
Boiling point | 750.8±60.0 °C(Predicted) |
Density | 1.163±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to at least 25 mg/ml). |
pka | 11.92±0.10(Predicted) |
form | solid |
color | Off-white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
NFPA 704 |
|
Tazemetostat (EPZ-6438) Chemical Properties,Uses,Production
Uses
EPZ 6438 is a potent and selective inhibitor of EZH2.
Biological Activity
Tazemetostat (EPZ-6438) is a potent, and selective EZH2 inhibitor with K i and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMT.
target
EZH2(Cell-free assay)
Tazemetostat (EPZ-6438) Preparation Products And Raw materials
Raw materials
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide
Benzoic acid, 5-broMo-2-Methyl-3-[(tetrahydro-2H-pyran-4-yl)aMino]-, Methyl ester
3-(aMinoMethyl)-4,6-diMethyl-1,2-dihydropyridin-2-one hydrochloride
Methyl 3-AMino-5-broMo-2-Methylbenzoate
5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE
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Global( 191)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | China | 973 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
1403254-99-8(Tazemetostat (EPZ-6438) )Related Search:
E-7438
EPZ-7438
N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide
[1,1'-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-
N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide EPZ6438
Henagliflozin Proline
Tazemetostat
EPZ-6438
EPZ-6438(E7438)
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino
CPDB1064
EPZ6438(Tazemetostat)
N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide
E7438, Tazemetostat
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)biphenyl-3-carboxamide
EPZ6438;EPZ 6438;E-7438;TAZEMETOSTAT
CS-971
E7438,EPZ6438, EPZ-6438
EPZ6438; EPZ 6438; E-7438
[1,1'-Biphenyl]-3-carboxamide
Tazemetostat (EPZ-6438) USP/EP/BP
N-[(4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-[ethyl(tetrahydropyran-4-yl)amino]-4-methyl-4'-(morpholinomethyl)biphenyl-3-carboxamide
EPZ-6438
Tazemetostat
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
EPZ6438 Tazemetostat EPZ-6438
EPZ 6438,epigenetic,inhibit,E 7438,Tazemetostat,Histone Methyltransferase,EPZ-6438,Inhibitor,E7438,EZH1,cancer,EZH2,PRC2
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
1403254-99-8
C34H44N4O4
Inhibitors