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Ivosidenib

CAS No.: 1448347-49-6

Chemical Name:: Ivosidenib

Synonyms: Ivosidenib;lvosidenib;RG120;CS-1721;EOS-60845;RG120 100MG;AG120;AG 120;AG-120 (RG120);Ivosidenib 13C5;Ivosidenib(AG-120)

CBNumber:: CB32738771

Molecular Formula:: C28H22ClF3N6O3

Molecular Weight:: 582.96

MOL File:: 1448347-49-6.mol

Modify Date:: 2023/12/28 17:45:33

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Ivosidenib Properties

Melting point	151-173°C
Boiling point	854.3±65.0 °C(Predicted)
Density	1.51±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	11.58±0.40(Predicted)
form	Solid
color	White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

Ivosidenib Chemical Properties,Uses,Production

Description

AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.

Uses

Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.

Ivosidenib Preparation Products And Raw materials

Raw materials

2-Chloro-4-cyanopyridine

Preparation Products

Ivosidenib Suppliers

Global( 148)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21663	55	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9261	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32835	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29821	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharma Affiliates	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58

The synthesis method of Ivosidenib
Ivosidenib is a first-in-class, oral small molecule, potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH....
Dec 28，2023

Ivosidenib Spectrum

RG120(1448347-49-6)¹HNMR

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AG120;AG 120 RG120 Ivosidenib CS-1721 lvosidenib RG120 100MG EOS-60845 Ivosidenib(AG-120) (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (2S)-1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)- Ivosidenib 13C5 (S)-N-[(S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridyl)-N-(5-fluoro-3-pyridyl)-5-oxopyrrolidine-2-carboxamide AG-120 (RG120) 1448347-49-6 API