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tasquinimod

CAS No.: 254964-60-8

Chemical Name:: tasquinimod

Synonyms: TASQ);ABR-215050;tasquinimod;Tasquinimod, >98%;Tasquinimod(ABR-215050);7-diMethoxy-4-quinolinyl)oxy]-;ABR-215050; ABR215050; ABR 215050;7-Dimethoxy-quinolin-4-yloxy)-phenylamine;4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide;4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-c

CBNumber:: CB61508619

Molecular Formula:: C20H17F3N2O4

Molecular Weight:: 406.36

MOL File:: 254964-60-8.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:13

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tasquinimod Properties

Boiling point	501.5±50.0 °C(Predicted)
Density	1.427±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	insoluble in H2O; ≥20.32 mg/mL in DMSO; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
form	solid
pka	4.50±1.00(Predicted)
color	White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

tasquinimod Chemical Properties,Uses,Production

Description

Tasquinimod is an orally-active quinoline-3-carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases. Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer. While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.

Uses

Tasquinimod is an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.

tasquinimod Preparation Products And Raw materials

Raw materials

2-Amino-6-methoxybenzoic acid 5-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione Methyl 4-hydroxy-5-Methoxy-1-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-5-Methoxy-1-Methyl-2-oxo- ethyl 4-hydroxy-5-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

4-TRIFLUOROMETHYL-N-METHYLANILINE 97 3-METHOXY-N-METHYLISATOIC ANHYDRIDE 2-Methoxy-6-(MethylaMino)benzoic acid 2,6-Difluorobenzonitrile

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Preparation Products

tasquinimod Suppliers

Global( 105)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

tasquinimod Spectrum

tasquinimod(254964-60-8)¹HNMR

254964-60-8(tasquinimod)Related Search:

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Iguratimod CIVENTICHEM CV-4057 BAF-312(SiponiMod)

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4-Hydroxy-5-methoxy-N-methyl-1-methyl-2-oxo-N-(4-trifluoromethylphenyl)-1,2-dihydroquinoline-3-carboxamide N-Methyl-N-(4-trifluoromethylphenyl)-1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxoquinoline-3-carboxamide tasquinimod ABR-215050 3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-5-Methoxy-N,1-diMethyl-2-oxo-N-[4-(trifluoroMethyl)phenyl]- 4-Hydroxy-5-Methoxy-1-Methyl-2-oxo-1,2- dihydro-quinoline-3-carboxylic acid Methyl- (4-trifluoroMethyl-phenyl)-aMide 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-trifluoromethyl)phenyl]-3-quinolinecarboxamide 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-c 4-Hydroxy-N-[4-(trifluoromethyl)phenyl]-5-methoxy-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide ABR-215050; ABR215050; ABR 215050 Tasquinimod, >98% Tasquinimod(ABR-215050) TASQ) 7-diMethoxy-4-quinolinyl)oxy]- 7-Dimethoxy-quinolin-4-yloxy)-phenylamine 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)phenyl)-1,2-dihydroquinoline-3-carboxamide 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide 254964-60-8 Angiogenesis inhibitor S100 calcium binding protein A9 modulator Inhibitors