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GNE-9605

CAS No.: 1536200-31-3

Chemical Name:: GNE-9605

Synonyms: CS-1831;GNE-9605;GNE-9605 USP/EP/BP;GNE-9605;GNE9605;GNE 9605;Diazepam-d8 (exempt preparation);N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;rel-N2-(5-Chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-

CBNumber:: CB72715631

Molecular Formula:: C17H20ClF4N7O

Molecular Weight:: 449.83

MOL File:: 1536200-31-3.mol

Modify Date:: 2024/7/2 8:55:16

Request For Quotation

GNE-9605 Properties

Boiling point	587.9±60.0 °C(Predicted)
Density	1.67±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	≥22.5 mg/mL in DMSO
form	solid
pka	5.04±0.60(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H302-H400-H410

Precautionary statements

P264-P270-P273-P301+P312-P330-P391-P501

NFPA 704

	0
2		0

GNE-9605 Chemical Properties,Uses,Production

Description

GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC₅₀ = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser¹²⁹² autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.

GNE-9605 Preparation Products And Raw materials

Raw materials

Preparation Products

GNE-9605 Suppliers

Global( 76)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24639	58	Inquiry
Henan Alfa Chemical Co., Ltd	+8618339805032	China	13187	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	China	9991	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	United States	19639	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Henan Alfa Chemical Co., Ltd	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aceschem Inc.	58

GNE-9605 Spectrum

GNE-9605(1536200-31-3)¹HNMR

1536200-31-3(GNE-9605)Related Search:

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PD 0332991 HCl Ibrutinib

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GNE-9605 N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine Diazepam-d8 (exempt preparation) CS-1831 GNE-9605;GNE9605;GNE 9605 2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel- GNE-9605 USP/EP/BP rel-N2-(5-Chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine 1536200-31-3 C17H20ClF4N7O Inhibitors