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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >GNF 5837

GNF 5837

GNF 5837 Structure
CAS No.
1033769-28-6
Chemical Name:
GNF 5837
Synonyms
CS-997;GNF 5837;GNF-5837, >97%;GNF-5837, >=98%;GNF5837; GNF 5837;GNF 5837 USP/EP/BP;GNF-5837, 10 mM in DMSO;Trk Inhibitor III, GNF-5837;Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem;(Z)-1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-
CBNumber:
CB62667487
Molecular Formula:
C28H21F4N5O2
Molecular Weight:
535.49
MOL File:
1033769-28-6.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

GNF 5837 Properties

Melting point >228°C (dec.)
Boiling point 616.0±55.0 °C(Predicted)
Density 1.497±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka 12.16±0.20(Predicted)
form powder
color yellow to orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H335-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  36/37/39
WGK Germany  3
NFPA 704
0
2 0

GNF 5837 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0844 GNF 5837 ≥98% (HPLC) 1033769-28-6 5MG ₹14418.9 2022-06-14 Buy
Sigma-Aldrich(India) SML0844 GNF 5837 ≥98% (HPLC) 1033769-28-6 25MG ₹58054.48 2022-06-14 Buy
Sigma-Aldrich(India) 648451 Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem The Trk Inhibitor III, GNF-5837 controls the biological activity of Trk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosp 1033769-28-6 10MG ₹23839.99 2022-06-14 Buy
Product number Packaging Price Buy
SML0844 5MG ₹14418.9 Buy
SML0844 25MG ₹58054.48 Buy
648451 10MG ₹23839.99 Buy

GNF 5837 Chemical Properties,Uses,Production

Uses

GNF 5837 is a potent pan-Trk inhibitor which has selectivity for tropomyosin-receptor-kinase (Trk).

Biochem/physiol Actions

GNF-5837 is an orally bioavailable Trk inhibitor (IC50 = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC50 values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.

GNF 5837 Preparation Products And Raw materials

Raw materials

BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER (4-BROMO-2-NITRO-PHENYL)-ACETIC ACID 4-Bromo-1-fluoro-2-nitrobenzene Pyrrole-2-carboxaldehyde

Preparation Products

GNF 5837 Suppliers

Global( 120)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6700 30 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Supplier Advantage
CHEMSWORTH 30
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

GNF 5837 Spectrum

GNF 5837(1033769-28-6)1HNMR

1033769-28-6(GNF 5837)Related Search:

GNE-3511 GNE-490 GNE-9605 GNE-6640 GNE 477
GNE-955 GNE140 GNE-493 gne-131 GNE 617
GNE 7915 WS6 Bosutinib Linifanib (ABT-869) (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Epothilone B Z-VAD-FMK
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Trk Inhibitor III, GNF-5837 GNF 5837 (Z)-1-(3-(3-((1H-PYRROL-2-YL)METHYLENE)-2-OXOINDOLIN-6-YLAMINO)-4-METHYLPHENYL)-3-(2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL)UREA N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea GNF 5837 N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea GNF5837 GNF-5837, >=98% 1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-(4-methyl-3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)urea (Z)-1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro- GNF 5837 USP/EP/BP Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem CS-997 GNF-5837, >97% GNF5837; GNF 5837 Urea, N-[3-[[2,3-dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]- 1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea GNF-5837, 10 mM in DMSO 1033769-28-6 C28H21F4N5O2 Inhibitors