ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >GNF 5837
GNF 5837
- CAS No.
- 1033769-28-6
- Chemical Name:
- GNF 5837
- Synonyms
- CS-997;GNF 5837;GNF-5837, >97%;GNF-5837, >=98%;GNF5837; GNF 5837;GNF 5837 USP/EP/BP;Trk Inhibitor III, GNF-5837;Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem;(Z)-1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-;1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
- CBNumber:
- CB62667487
- Molecular Formula:
- C28H21F4N5O2
- Molecular Weight:
- 535.49
- MOL File:
- 1033769-28-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
GNF 5837 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0844 | GNF 5837 ≥98% (HPLC) | 1033769-28-6 | 5MG | ₹14418.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0844 | GNF 5837 ≥98% (HPLC) | 1033769-28-6 | 25MG | ₹58054.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 648451 | Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem The Trk Inhibitor III, GNF-5837 controls the biological activity of Trk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosp | 1033769-28-6 | 10MG | ₹23839.99 | 2022-06-14 | Buy |
GNF 5837 Chemical Properties,Uses,Production
Uses
GNF 5837 is a potent pan-Trk inhibitor which has selectivity for tropomyosin-receptor-kinase (Trk).
Biochem/physiol Actions
GNF-5837 is an orally bioavailable Trk inhibitor (IC50 = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC50 values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.
GNF 5837 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 105)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24607 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| BOC Sciences | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| Dideu Industries Group Limited | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | 58 |
| InvivoChem | 58 |
1033769-28-6(GNF 5837)Related Search:
Trk Inhibitor III, GNF-5837
GNF 5837
(Z)-1-(3-(3-((1H-PYRROL-2-YL)METHYLENE)-2-OXOINDOLIN-6-YLAMINO)-4-METHYLPHENYL)-3-(2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL)UREA
N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
GNF 5837 N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea GNF5837
GNF-5837, >=98%
1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-(4-methyl-3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)urea
(Z)-1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-
GNF 5837 USP/EP/BP
Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem
CS-997
GNF-5837, >97%
GNF5837; GNF 5837
Urea, N-[3-[[2,3-dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-
1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
1033769-28-6
C28H21F4N5O2
Inhibitors