Fingolimod hydrochloride
- CAS No.
- 162359-56-0
- Chemical Name:
- Fingolimod hydrochloride
- Synonyms
- Gilenya;FTY720;Fingolimod HCl;Fin;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;FY720;CS-290;FTY-720A;FTY720 . HCl;Fingolimod HC
- CBNumber:
- CB4244536
- Molecular Formula:
- C19H34ClNO2
- Molecular Weight:
- 343.93
- MOL File:
- 162359-56-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 19:22:53
| Melting point | 102-107°C |
|---|---|
| storage temp. | -20°C |
| solubility | water: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| Merck | 14,4083 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
| CAS DataBase Reference | 162359-56-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260-P314-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-52/53 |
| Safety Statements | 26-61 |
| WGK Germany | 3 |
| RTECS | TY3130000 |
| HS Code | 29221990 |
| Toxicity | LD50 orally in rats: 300-600 mg/kg (Troncoso) |
Fingolimod hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0700 | FTY720 ≥98% (HPLC) | 162359-56-0 | 5MG | ₹7068.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0700 | FTY720 ≥98% (HPLC) | 162359-56-0 | 25MG | ₹28956.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2790 | Fingolimod Hydrochloride | 162359-56-0 | 500MG | ₹100932.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F1018 | Fingolimod Hydrochloride | 162359-56-0 | 200MG | ₹8800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F1018 | Fingolimod Hydrochloride | 162359-56-0 | 1G | ₹18200 | 2022-05-26 | Buy |
Fingolimod hydrochloride Chemical Properties,Uses,Production
Description
Approved by the U.S. FDA in September 2010, fingolimod (also referred to as FTY720) is the first approved oral therapy for the relapsing-remitting form ofmultiple sclerosis (RRMS). Because of fingolimod’s structural resemblance to sphingosine, a metabolite of sphingolipids that constitutes the cell membrane of all eukaryotic cells, it was hypothesized that fingolimod may be affecting sphingolipid metabolism in cells. A series of elegant in vitro and in vivo studies confirmed that fingolimod is converted to (S)-fingolimod phosphate primarily by sphingosine kinase- 2 and that (S)-fingolimod phosphate mediates multiple biological processes by binding to novel GPCR’s referred to as sphingosine-1-phosphate (S1P) receptors. S1P receptors are divided into five subtypes, S1P1–5, which have varying tissue and cellular distribution. S1P1–3 receptors are ubiquitously expressed in the immune, cardiovascular, and central nervous systems, S1P4 is restricted to the hematopoietic system, and S1P5 is mostly localized in the white matter of CNS. S1P1–3 receptors play important roles in endothelial barrier function, maintaining vascular tone, regulating heart rate and allowing for lymphocyte egress fromsecondary lymphoid organs. The functional role of S1P4 is unknown,while the S1P5 receptor is thought to be involved in natural killer cell trafficking and oligodendrocyte function.
Chemical Properties
White Solid
Uses
Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Definition
ChEBI: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Clinical Use
Fingolimod hydrochloride is an immunosuppressive drug developed by Novartis and approved in the U.S., Europe, and Australia in 2010 for the treatment of multiple sclerosis. The structure of fingolimod derives from the naturally-occurring myriocin (ISP-1) metabolite of the fungus I. sinclairii and the aminoalcohol functionality within the drug possesses structural similarity to the sphingosine family of natural products.
Fingolimod hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Prajna generics pvt ltd | +91-9441174873 +91-9441174873 | Hyderabad, India | 24 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Opulant Pharmaceuticals Pvt Ltd | +91-8105130349 +91-8105130349 | Telangana, India | 66 | 58 | Inquiry |
| Ascott Pharma | +91-9825331440 +91-9825331440 | Gujarat, India | 7 | 58 | Inquiry |
| Acute Research | +91-9825068697 +91-9825068697 | Gujarat, India | 43 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Dr. Reddy's Laboratories Ltd | 58 |
| Prajna generics pvt ltd | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Alembic Pharmaceuticals Limited | 58 |
| Honour Lab Limited | 58 |
| Hetero Drugs Limited | 58 |
| Shilpa Medicare Limited (SML) | 58 |
| Opulant Pharmaceuticals Pvt Ltd | 58 |
| Ascott Pharma | 58 |
| Acute Research | 58 |
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