ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >FAK inhibitors >TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226)

CAS No.: 761437-28-9

Chemical Name:: TAE226 (NVP-TAE226)

Synonyms: TAE226;CS-1694;NVP-TAE 226;TAE-226, >98%;TAE226 (NVP-TAE226);TAE226 (NVP-TAE226), >98%;TAE226 (NVP-TAE226) USP/EP/BP;TAE226; TAE-226;TAE 226;NVPTAE226;2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

CBNumber:: CB32589634

Molecular Formula:: C23H25ClN6O3

Molecular Weight:: 468.94

MOL File:: 761437-28-9.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:06

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TAE226 (NVP-TAE226) Properties

Density	1.349
storage temp.	Store at -20°C
solubility	≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	solid
pka	14.57±0.46(Predicted)
color	White to khaki

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

TAE226 (NVP-TAE226) Chemical Properties,Uses,Production

Description

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC₅₀ = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC₅₀ = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC₅₀ = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.

Uses

NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.

TAE226 (NVP-TAE226) Preparation Products And Raw materials

Raw materials

Preparation Products

TAE226 (NVP-TAE226) Suppliers

Global( 101)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32835	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29899	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49403	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	23499	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	China	9991	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

TAE226 (NVP-TAE226) Spectrum

TAE226 (NVP-TAE226)(761437-28-9)¹HNMR

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NVP-CGM097 NVP-BEP800 Siremadlin NVP-BAW2881 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride

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NVP-TAE 226 TAE226 TAE226 (NVP-TAE226) 2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl- NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide TAE226 (NVP-TAE226), >98% TAE-226, >98% TAE226; TAE-226;TAE 226;NVPTAE226 CS-1694 TAE226 (NVP-TAE226) USP/EP/BP 761437-28-9 Inhibitors