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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Proteasome inhibitors >(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Structure
CAS No.
1072833-77-2
Chemical Name:
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
Synonyms
IxazoMib;MLN2238;Ixazomib-d7;CS-1976;MLN2238(Ixazomib);MLN2238(iaxzomib);ixazomib(MLN2238);Ixazomib (MLN-9708);Ixazomib (10mM in DMSO);MLN2238;MLN 2238;MLN-2238
CBNumber:
CB62521080
Molecular Formula:
C14H19BCl2N2O4
Molecular Weight:
361.03
MOL File:
1072833-77-2.mol
Modify Date:
2024/3/28 13:39:29
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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Properties

Melting point >142°C (subl.)
Density 1.306
storage temp. -20°C Freezer
solubility DMSO (Sparingly), Methanol (Slightly)
pka 9.67±0.43(Predicted)
form Solid
color White to Pale Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H362-H360
Precautionary statements  P201-P260-P263-P264-P270-P308+P313

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Chemical Properties,Uses,Production

Uses

Ixazomib is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.

Definition

ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixa omib citrate, it is used in combination therapy for treatment of multiple myeloma.

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Suppliers

Global( 194)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CDYMAX +91-9019317788 +91-9019317788 Bangalore, India 28 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Henan Fengda Chemical Co., Ltd +86-371-86557731 +86-13613820652 China 20294 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 18648 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21667 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Supplier Advantage
CDYMAX 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Henan Fengda Chemical Co., Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Spectrum

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid(1072833-77-2)MS

1072833-77-2((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid)Related Search:

Ixazomib citrate (USAN) Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]- Ixazomib Impurity 1 CUDC-101 Brivanib alaninate
AC480 (BMS-599626) 1H-indazole-7-carboxylic acid tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Niraparib (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate
Piperidine, 3-(4-bromophenyl)- (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate 4-piperidin-3-ylaniline CHEMBRDG-BB 7959525 Methyl 3-formyl-2-nitrobenzoate
Bortezomib MLN9708 MK-2206 2HCl
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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid ixazomib(MLN2238) B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid Ixazomib (MLN2238) MLN2238(iaxzomib) MLN2238(Ixazomib) MLN2238;MLN 2238;MLN-2238 IXAZOMIB;MLN 2238;MLN-2238 CS-1976 1-(2-(2,5-dichlorobenzamido)acetamido)- 3-methylbutylboronic acid Ixazomib (MLN-9708) Ixazomib, 98%, a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM) (1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid Boronic acid, B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]- (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbuyl)boronic acid Ixazomib (10mM in DMSO) Ixazomib-13C2,15NQ: What is Ixazomib-13C2,15N Q: What is the CAS Number of Ixazomib-13C2,15N MLN2238 IxazoMib Ixazomib-d7 1072833-77-2 C14H19BCl2N2O4 Inhibitors Inhibitor apis