DO264
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- ₹0
- Product name: DO264
- CAS: 2301866-59-9
- MF: C23H20Cl2F3N5O2S
- MW: 558.4
- EINECS:604-604-1
- MDL Number:MFCD31812603
- Synonyms:N-[1-[3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinylthiourea;Thiourea, N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-;DO264;DO-264;DO 264;DO264 (DO-264;DO264
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Properties
Boiling point :601.5±65.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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Description
DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM). It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. DO264 increases levels of chemokine (C-C motif) ligand 3 (CCL3), CCL4, TNF-α, and IL-1β in M1-polarized THP-1 macrophages. It potentiates ferroptotic cell death induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in HT1080 fibrosarcoma and SU-DHL-5 B cell lymphoma cells when used at a concentration of 1 μM. In vivo, DO264 (30 mg/kg per day for four weeks) increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS, 1-docosanoyl-2-hydroxy-sn-glycero-3-PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS, and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain. It increases levels of CCL2, CCL3, and CCL5 in bronchoalveolar lavage fluid (BALF) and decreases survival in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) clone 13 when administered at a dose of 30 mg/kg.Related product price
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Suzhou Chenrui Biotechnology Co. LTD
RD International Technology Co., Limited
Chunchuang (Wuhan) Technology Co., Ltd