NVP-BEP800
- ₹0
- Product name: NVP-BEP800
- CAS: 847559-80-2
- MF: C21H23Cl2N5O2S
- MW: 480.41
- EINECS:-0
- MDL Number:MFCD18251568
- Synonyms:NVP-BEP800;2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide;NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide;VER82576;VER-82576;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP 800;NVP-BEP 800 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
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Properties
Density :1.396
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form :Powder
pka :13.25±0.46(Predicted)
color :White to off-white
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form :Powder
pka :13.25±0.46(Predicted)
color :White to off-white
Safety Information
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Description
Heat shock protein 90 (Hsp90) isoforms are molecular chaperones that modulate intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin , have shown promise as anti-tumor agents. NVP-BEP800 is a potent inhibitor of Hsp90β (IC50 = 58 nM) that is 70-fold less effective against two related Hsps, Grp94 (Hsp90B1) and Trap-1 (Hsp75). It is without effect (IC50 > 10 μM) against a panel of twenty kinases. NVP-BEP800 causes p23/Hsp90 dissociation and client protein degradation, which leads to growth inhibition (GI50s from 53 to 190 nM) or induction of cell death in cancer cell lines. It is orally available and has antitumor effects in human tumor xenografts in mice. Hsp90 inhibitors, including NVP-BEP800, increase the sensitivity of tumor cells to ionizing radiation. They also direct the proteasomal degradation of viral Hsp90 client proteins, including those required for latency and infectivity of Kaposi sarcoma-associated herpes virus.Related product price
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
changzhou huayang technology co., ltd
InvivoChem
Hunan Jibang Biological Technology Co., LTD