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ChemicalBook >> CAS DataBase List >> NVP-BEP800

NVP-BEP800

NVP-BEP800 price.
  • $44 - $3384.15
  • Product name: NVP-BEP800
  • CAS: 847559-80-2
  • MF: C21H23Cl2N5O2S
  • MW: 480.41
  • EINECS:-0
  • MDL Number:MFCD18251568
  • Synonyms:NVP-BEP800;2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide;NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide;VER82576;VER-82576;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP 800;NVP-BEP 800 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
28 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 500μg
  • 1MG
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200MG
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7557
  • Product descriptionNVP-BEP800
  • Packaging10mg
  • Price$411
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004937
  • Product descriptionNVP-BEP800 95.00%
  • Packaging1MG
  • Price$182.7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004937
  • Product descriptionNVP-BEP800 95.00%
  • Packaging10MG
  • Price$1006.58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004937
  • Product descriptionNVP-BEP800 95.00%
  • Packaging200MG
  • Price$3384.15
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4064
  • Product descriptionNVP-BEP800
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4064
  • Product descriptionNVP-BEP800
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4064
  • Product descriptionNVP-BEP800
  • Packaging25mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4064
  • Product descriptionNVP-BEP800
  • Packaging100mg
  • Price$960
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180788
  • Product descriptionNVP-BEP800 >99%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180788
  • Product descriptionNVP-BEP800 >99%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180788
  • Product descriptionNVP-BEP800 >99%
  • Packaging1g
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18383
  • Product descriptionNVP-BEP800 ≥98%
  • Packaging500μg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18383
  • Product descriptionNVP-BEP800 ≥98%
  • Packaging1mg
  • Price$78
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18383
  • Product descriptionNVP-BEP800 ≥98%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18383
  • Product descriptionNVP-BEP800 ≥98%
  • Packaging10mg
  • Price$281
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM151593
  • Product description2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 98%
  • Packaging100mg
  • Price$774
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7557 NVP-BEP800 10mg $411 2021-12-16 Buy
American Custom Chemicals Corporation INB0004937 NVP-BEP800 95.00% 1MG $182.7 2021-12-16 Buy
American Custom Chemicals Corporation INB0004937 NVP-BEP800 95.00% 10MG $1006.58 2021-12-16 Buy
American Custom Chemicals Corporation INB0004937 NVP-BEP800 95.00% 200MG $3384.15 2021-12-16 Buy
ApexBio Technology A4064 NVP-BEP800 5mg $110 2021-12-16 Buy
ApexBio Technology A4064 NVP-BEP800 10mg $190 2021-12-16 Buy
ApexBio Technology A4064 NVP-BEP800 25mg $410 2021-12-16 Buy
ApexBio Technology A4064 NVP-BEP800 100mg $960 2021-12-16 Buy
Biorbyt Ltd orb180788 NVP-BEP800 >99% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb180788 NVP-BEP800 >99% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb180788 NVP-BEP800 >99% 1g $2245.7 2021-12-16 Buy
Cayman Chemical 18383 NVP-BEP800 ≥98% 500μg $44 2024-03-01 Buy
Cayman Chemical 18383 NVP-BEP800 ≥98% 1mg $78 2024-03-01 Buy
Cayman Chemical 18383 NVP-BEP800 ≥98% 5mg $193 2024-03-01 Buy
Cayman Chemical 18383 NVP-BEP800 ≥98% 10mg $281 2024-03-01 Buy
Chemenu CM151593 2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 98% 100mg $774 2021-12-16 Buy

Properties

Density :1.396
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form :Powder
pka :13.25±0.46(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Heat shock protein 90 (Hsp90) isoforms are molecular chaperones that modulate intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin , have shown promise as anti-tumor agents. NVP-BEP800 is a potent inhibitor of Hsp90β (IC50 = 58 nM) that is 70-fold less effective against two related Hsps, Grp94 (Hsp90B1) and Trap-1 (Hsp75). It is without effect (IC50 > 10 μM) against a panel of twenty kinases. NVP-BEP800 causes p23/Hsp90 dissociation and client protein degradation, which leads to growth inhibition (GI50s from 53 to 190 nM) or induction of cell death in cancer cell lines. It is orally available and has antitumor effects in human tumor xenografts in mice. Hsp90 inhibitors, including NVP-BEP800, increase the sensitivity of tumor cells to ionizing radiation. They also direct the proteasomal degradation of viral Hsp90 client proteins, including those required for latency and infectivity of Kaposi sarcoma-associated herpes virus.

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