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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Apoptosis >Bcl-2 inhibitors >UMI-77

UMI-77

UMI-77 Structure
  • ₹0
  • Product name: UMI-77
  • CAS: 518303-20-3
  • MF: C18H14BrNO5S2
  • MW: 468.34
  • EINECS:
  • MDL Number:MFCD03471890
  • Synonyms:2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid;UMI-77;2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid;2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77;Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-;UMI 77;UMI77;CS-1799;UMI-77 USP/EP/BP
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :661.2±65.0 °C(Predicted)
Density :1.79±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form :solid
pka :2.41±0.30(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Myeloid cell leukemia-1 (Mcl-1) is a potent anti-apoptotic protein and a member of the pro-survival Bcl-2 family. UMI-77 is a selective Mcl-1 inhibitor with a Ki value of 490 nM and exhibits selectivity over other members of the Bcl-2 family (Kis = 5.3, 23.8, 33.0, and 8.2 μM) for A1/Bfl-1, Bcl-2, Bcl-xL, and Bcl-W, respectively). It has been shown to disrupt the heterodimerization of Mcl-1/Bax and Mcl-1/Bak, thus antagonizing Mcl-1 function. UMI-77 inhibits the growth of various pancreatic cancer cell lines with IC50s values ranging from 3.4-16.1 μM, inducing apoptosis through activation of the intrinsic apoptotic pathway and/or Bax conformational change. In a BxPC-3 xenograft mouse model, 60 mg/kg UMI-77 demonstrated antitumor activity without damaging normal tissues.

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Suppliers and manufacturers

career henan chemical co
Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?-
₹1.00 /1KG
Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?- CAS:518303-20-3
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Hebei Miaoyin Technology Co.,Ltd