Panobinostat
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- Product name: Panobinostat
- CAS: 404950-80-7
- MF: C21H23N3O2
- MW: 349.43
- EINECS:803-814-1
- MDL Number:MFCD09833242
- Synonyms:(E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE;N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide;LBH-589/Panobinostat;LBH-589;PANOBINOSTAT;2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)-, (2E)-;NVP-LBH589;Panobinostat (LBH589)
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Properties
Melting point :114-117?C
Density :1.241±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
form :solid
pka :8.71±0.23(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Density :1.241±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
form :solid
pka :8.71±0.23(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
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Description
Panobinostat is a potent inhibitor of all histone deacetylases (HDACs), with Ki values ranging from 0.6 to 31 nM for HDAC1-11. Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells. It has potential applications in several different forms of cancer as well as in spinal muscular atrophy and HIV therapy.More related product prices
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