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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antifungal Drugs >Itraconazole

Itraconazole

Itraconazole Structure
  • ₹10900 - ₹23111.38
  • Product name: Itraconazole
  • CAS: 84625-61-6
  • MF: C35H38Cl2N8O4
  • MW: 705.63
  • EINECS:617-596-9
  • MDL Number:MFCD00870168
  • Synonyms:Oriconazole, R51211, Sporanox;4-[4-[4-[4-[[2-(2，4-Dichlomphenyl)-2-(1H-1，2，4-tfiazol-1- yl-methyl)-1,3-dioxolan-4-y1]methoxyl]phenyl]-1-piperazinyl]phenyl]-2，4-dihydro-2-(1-methylpropyl)-3H-1，2，4-triazol-3-one;Oricomzole;Oyiconazole;3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)- 1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;Canditral;Sporamelt;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1-methylpropyl)-2,4-dihydro-1,2,4-triazol-3-one
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 200MG
  • 250MG
  • 1ML
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberI0732
  • Product descriptionItraconazole
  • Packaging5G
  • Price₹10900
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberI0732
  • Product descriptionItraconazole
  • Packaging25G
  • Price₹20800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI-015
  • Product descriptionItraconazole solution 2.0?mg/mL (Methanol with 1% 1M HCl), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹11251.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number419825
  • Product descriptionHh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule
  • Packaging250MG
  • Price₹14100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1834
  • Product descriptionItraconazole Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging200MG
  • Price₹18037.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI6657
  • Product descriptionItraconazole ≥98% (TLC)
  • Packaging100MG
  • Price₹23111.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) I0732 Itraconazole 5G ₹10900 2022-05-26 Buy
TCI Chemicals (India) I0732 Itraconazole 25G ₹20800 2022-05-26 Buy
Sigma-Aldrich(India) I-015 Itraconazole solution 2.0?mg/mL (Methanol with 1% 1M HCl), ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹11251.8 2022-06-14 Buy
Sigma-Aldrich(India) 419825 Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule 250MG ₹14100 2022-06-14 Buy
Sigma-Aldrich(India) PHR1834 Itraconazole Pharmaceutical Secondary Standard; Certified Reference Material 200MG ₹18037.5 2022-06-14 Buy
Sigma-Aldrich(India) I6657 Itraconazole ≥98% (TLC) 100MG ₹23111.38 2022-06-14 Buy

Properties

Melting point :166°C
Boiling point :850.0±75.0 °C(Predicted)
alpha :-0.1～+0.1°(D/20℃)(c=10,CH2Cl2)
Density :1.27 g/cm3
Flash point :>110°(230°F)
storage temp. :2-8°C
solubility :chloroform: 50 mg/mL, clear, colorless
pka :3.7(at 25℃)
form :White powder
color :white
Water Solubility :Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol
Merck :14,5245
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :VHVPQPYKVGDNFY-UHFFFAOYSA-N
CAS DataBase Reference :84625-61-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The Hedgehog signaling pathway is critical for embryonic growth and patterning as well as stem cell and progenitor cell tissue homeostasis. Inappropriate Hedgehog activity has been linked to tumor formation. Itraconazole is a systemic antifungal agent with a distinct antagonist effect on Hedgehog signaling. With an IC50 value of 0.8 μM in vitro, itraconazole behaves as an inverse agonist downstream of Patched (Ptch), yet upstream of Smoothened (Smo) to disrupt Hedgehog signaling. Treatment with 100 mg/kg itraconazole twice per day has been shown to suppress the growth of medulloblastomas from a Ptch+/-p53-/- mouse allograft model in as few as five days.

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Suppliers and manufacturers

Jigs Chemical ltd HEMA PHARMACEUTICALS PVT LTD SGMR PHARMACEUTICALS PVT LTD ANWITA APIS J S LABS TYNDAL LABS PVT LTD Shree HariKrishna Pharmaceuticals Metrochem API Private Limited Styrax Pharma Pvt Ltd Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd)