8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
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- ₹5600 - ₹65545.5
- Product name: 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
- CAS: 155270-99-8
- MF: C20H24N4O4
- MW: 384.43
- EINECS:
- MDL Number:MFCD00928421
- Synonyms:8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione;istradefylline;KW-6002;10mg 50mg 100mg 1g 5g;(E)-8-(3,4-diMethoxystyryl)-1,3-diethyl-7-Methyl-1H-purine-2,6(3H,7H)-dione;8-[(E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-7-Methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione;Istradefylline (KW-6002);1H-Purine-2,6-dione,8-[(1E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-Methyl-
4 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
- TCI Chemicals (India)
Package
- 5MG
- 25MG
- 250MG
- 1G
- ManufacturerSigma-Aldrich(India)
- Product numberSML0422
- Product descriptionIstradefylline ≥98% (HPLC)
- Packaging5MG
- Price₹15850.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0422
- Product descriptionIstradefylline ≥98% (HPLC)
- Packaging25MG
- Price₹65545.5
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberI1100
- Product descriptionIstradefylline
- Packaging1G
- Price₹9800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberI1100
- Product descriptionIstradefylline
- Packaging250MG
- Price₹5600
- Updated2022-05-26
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0422 | Istradefylline ≥98% (HPLC) | 5MG | ₹15850.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0422 | Istradefylline ≥98% (HPLC) | 25MG | ₹65545.5 | 2022-06-14 | Buy |
TCI Chemicals (India) | I1100 | Istradefylline | 1G | ₹9800 | 2022-05-26 | Buy |
TCI Chemicals (India) | I1100 | Istradefylline | 250MG | ₹5600 | 2022-05-26 | Buy |
Properties
Melting point :191 °C
Boiling point :601.0±65.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
form :powder
pka :0.47±0.70(Predicted)
color :white to beige
InChIKey :IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS DataBase Reference :155270-99-8
Boiling point :601.0±65.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
form :powder
pka :0.47±0.70(Predicted)
color :white to beige
InChIKey :IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS DataBase Reference :155270-99-8
Safety Information
Symbol(GHS): |
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Signal word: | Danger | ||||||||||||||
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Description
In March 2013, istradefylline (also known as KW-6002) was approved in Japan for adjunctive treatment of Parkinson’s disease (PD). Istradefylline acts by antagonism of the adenosine A2A receptor, which is colocalized with dopamine D2 receptors in the striatum, to enhance dopamine D2-dependent signaling. Istradefylline is a light-sensitive compound and has been evaluated in vitro under low-light conditions to prevent isomerization of the (E)-styryl group and decomposition. Istradefylline has a Ki of 2.2 nM for the rat adenosine A2A receptor and an ED50 of 0.03 mg/kg, po, in reversal of haloperidol-induced catalepsy in mice. Further characterization showed istradefylline to have a Ki of 12 nM for the human adenosine A2A receptor, to be highly selective, and to be a functional competitive antagonist. Istradefylline has activity alone and in combination with levo-dopa in preclinical animal models of PD. The synthesis of istradefylline was accomplished by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated coupling of 5,6-diamino-1,3-diethyluracil with 3,4-dimethoxycinnamic acid, followed by cyclization upon treatment with aqueous NaOH, and selective methylation (MeI, K2CO3, and DMF).Related product price
- Itraconazole
₹10900-23111.38 - Everolimus
₹11709-51483.7 - 3,4-Dimethoxycinnamic acid
₹3400-3907.83
Suppliers and manufacturers
Firsky International Trade (Wuhan) Co., Ltd
₹30.00/KG
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
Wuhan Ruichi Technology Co., Ltd
SKVen Technologies Pvt.Ltd.
CLEARSYNTH LABS LTD.
A.J Chemicals
TCI Chemicals (India) Pvt. Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
₹30.00 /1KG
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8