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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >GPCR & G Protein >Adenosine Receptor Antagonists >8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Structure
  • ₹5600 - ₹65545.5
  • Product name: 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
  • CAS: 155270-99-8
  • MF: C20H24N4O4
  • MW: 384.43
  • EINECS:
  • MDL Number:MFCD00928421
  • Synonyms:8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione;istradefylline;KW-6002;10mg 50mg 100mg 1g 5g;(E)-8-(3,4-diMethoxystyryl)-1,3-diethyl-7-Methyl-1H-purine-2,6(3H,7H)-dione;8-[(E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-7-Methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione;Istradefylline (KW-6002);1H-Purine-2,6-dione,8-[(1E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-Methyl-
4 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)

Package

  • 5MG
  • 25MG
  • 250MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0422
  • Product descriptionIstradefylline ≥98% (HPLC)
  • Packaging5MG
  • Price₹15850.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0422
  • Product descriptionIstradefylline ≥98% (HPLC)
  • Packaging25MG
  • Price₹65545.5
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberI1100
  • Product descriptionIstradefylline
  • Packaging1G
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberI1100
  • Product descriptionIstradefylline
  • Packaging250MG
  • Price₹5600
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0422 Istradefylline ≥98% (HPLC) 5MG ₹15850.8 2022-06-14 Buy
Sigma-Aldrich(India) SML0422 Istradefylline ≥98% (HPLC) 25MG ₹65545.5 2022-06-14 Buy
TCI Chemicals (India) I1100 Istradefylline 1G ₹9800 2022-05-26 Buy
TCI Chemicals (India) I1100 Istradefylline 250MG ₹5600 2022-05-26 Buy

Properties

Melting point :191 °C
Boiling point :601.0±65.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
form :powder
pka :0.47±0.70(Predicted)
color :white to beige
InChIKey :IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS DataBase Reference :155270-99-8

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

In March 2013, istradefylline (also known as KW-6002) was approved in Japan for adjunctive treatment of Parkinson’s disease (PD). Istradefylline acts by antagonism of the adenosine A2A receptor, which is colocalized with dopamine D2 receptors in the striatum, to enhance dopamine D2-dependent signaling. Istradefylline is a light-sensitive compound and has been evaluated in vitro under low-light conditions to prevent isomerization of the (E)-styryl group and decomposition. Istradefylline has a Ki of 2.2 nM for the rat adenosine A2A receptor and an ED50 of 0.03 mg/kg, po, in reversal of haloperidol-induced catalepsy in mice. Further characterization showed istradefylline to have a Ki of 12 nM for the human adenosine A2A receptor, to be highly selective, and to be a functional competitive antagonist. Istradefylline has activity alone and in combination with levo-dopa in preclinical animal models of PD. The synthesis of istradefylline was accomplished by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated coupling of 5,6-diamino-1,3-diethyluracil with 3,4-dimethoxycinnamic acid, followed by cyclization upon treatment with aqueous NaOH, and selective methylation (MeI, K2CO3, and DMF).

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