8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
![8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Structure](CAS/GIF/155270-99-8.gif)
- CAS No.
- 155270-99-8
- Chemical Name:
- 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
- Synonyms
- CS-285;KW-6002;Itraphylline;stradefylline;istradefylline;10mg 50mg 100mg 1g 5g;Istradefylline-13C-d3;KW6002/Istradefylline;Istradefylline (KW-6002);Itraphylline impurities5
- CBNumber:
- CB11261287
- Molecular Formula:
- C20H24N4O4
- Molecular Weight:
- 384.43
- MOL File:
- 155270-99-8.mol
- Modify Date:
- 2024/1/3 13:33:01
Melting point | 191 °C |
---|---|
Boiling point | 601.0±65.0 °C(Predicted) |
Density | 1.24±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: soluble5mg/mL (clear solution) |
form | powder |
pka | 0.47±0.70(Predicted) |
color | white to beige |
InChIKey | IQVRBWUUXZMOPW-PKNBQFBNSA-N |
CAS DataBase Reference | 155270-99-8 |
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0422 | Istradefylline ≥98% (HPLC) | 155270-99-8 | 5MG | ₹15850.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0422 | Istradefylline ≥98% (HPLC) | 155270-99-8 | 25MG | ₹65545.5 | 2022-06-14 | Buy |
TCI Chemicals (India) | I1100 | Istradefylline | 155270-99-8 | 250MG | ₹5600 | 2022-05-26 | Buy |
TCI Chemicals (India) | I1100 | Istradefylline | 155270-99-8 | 1G | ₹9800 | 2022-05-26 | Buy |
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Chemical Properties,Uses,Production
Description
In March 2013, istradefylline (also known as KW-6002) was approved in Japan for adjunctive treatment of Parkinson’s disease (PD). Istradefylline acts by antagonism of the adenosine A2A receptor, which is colocalized with dopamine D2 receptors in the striatum, to enhance dopamine D2-dependent signaling. Istradefylline is a light-sensitive compound and has been evaluated in vitro under low-light conditions to prevent isomerization of the (E)-styryl group and decomposition. Istradefylline has a Ki of 2.2 nM for the rat adenosine A2A receptor and an ED50 of 0.03 mg/kg, po, in reversal of haloperidol-induced catalepsy in mice. Further characterization showed istradefylline to have a Ki of 12 nM for the human adenosine A2A receptor, to be highly selective, and to be a functional competitive antagonist. Istradefylline has activity alone and in combination with levo-dopa in preclinical animal models of PD. The synthesis of istradefylline was accomplished by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated coupling of 5,6-diamino-1,3-diethyluracil with 3,4-dimethoxycinnamic acid, followed by cyclization upon treatment with aqueous NaOH, and selective methylation (MeI, K2CO3, and DMF).
Uses
Treatment of Parkinson’s disease (adenosine A 2A receptor antagonist).
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
SKVen Technologies Pvt.Ltd. | +91-7032295152 +91-7032295152 | Hyderabad, India | 81 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | China | 436 | 58 | Inquiry |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | China | 294 | 58 | Inquiry |
Wuhan Ruichi Technology Co., Ltd | +8613545065237 | China | 161 | 58 | Inquiry |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18648 | 58 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
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