Caffeic acid
- CAS No.
- 331-39-5
- Chemical Name:
- Caffeic acid
- Synonyms
- 3,4-DIHYDROXYCINNAMIC ACID;Caffeic;31-39-5;(E)-3-(3,4-Dihydroxyphenyl)acrylic acid;CAFFIC ACID;3-(3,4-DIHYDROXYPHENYL)ACRYLIC ACID;Caffeic acid 0;4-(2’-carboxyvinyl)-1,2-dihydroxybenzene;β-(3;NSC 623438
- CBNumber:
- CB6281061
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MOL File:
- 331-39-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 211-213 °C (dec.) (lit.) |
|---|---|
| Boiling point | 272.96°C (rough estimate) |
| Density | 1.2933 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL |
| form | powder |
| pka | 4.58±0.10(Predicted) |
| color | yellow to tan |
| Water Solubility | soluble in hot water |
| Merck | 14,1635 |
| BRN | 2210883 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | QAIPRVGONGVQAS-DUXPYHPUSA-N |
| LogP | 1.150 |
| CAS DataBase Reference | 331-39-5(CAS DataBase Reference) |
| IARC | 2B (Vol. 56) 1993 |
| NIST Chemistry Reference | Cinnamic acid, 3,4-dihydroxy-(331-39-5) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)- (331-39-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-40-63-68 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD8950000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29182990 | |||||||||
| Hazardous Substances Data | 331-39-5(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Caffeic acid price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C0625 | Caffeic acid ≥98.0% (HPLC) | 331-39-5 | 2G | ₹5964.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0625 | Caffeic acid ≥98.0% (HPLC) | 331-39-5 | 5G | ₹10511.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0625 | Caffeic acid ≥98.0% (HPLC) | 331-39-5 | 25G | ₹12351.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.22029 | 3,4-Dihydroxycinnamic acid for synthesis | 331-39-5 | 10G | ₹7430 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 60018 | Caffeic acid matrix substance for MALDI-MS, ≥99.0% (HPLC) | 331-39-5 | 1G | ₹7772.35 | 2022-06-14 | Buy |
Caffeic acid Chemical Properties,Uses,Production
Description
Caffeic acid is abundant in the whole plant of Solidago decurrens Lour. (Yi Zhi
Huang Hua), fruit of Crataegus pinnatifida Bge. var. major N.E.Br. (Shan Li
Hong), Salix myrtillacea Anderss. (Po Liu), rhizome of Cimicifuga foetida L., rhizome of Polypodiaceae Polypodium vulgare L. (Ou Ya Shui Long Gu), peel of
Rutaceae Citrus limonum (Ning Meng), the whole plant of Polygonaceae Polygonum
aviculare L. (Pian Xu), root of Valeriana officinalis L. (Xie Cao), the whole plant of
Thymus mongolicus Ronn (She Xiang), leaves of Eucommia ulmoides (Du Zhong),
and other herbal plants. It is a kind of polyhydroxy styrene acid, with the general
chemical properties of phenolic acid. It is easily oxidized for the reason of the unsaturated double bonds, particularly unstable in alkaline solution
Caffeic acid has both cis and trans isomers, and the two isomers of caffeic acid
have a mutual transformation in plants, which may regulate some important physiological process. Caffeic acid exists in plants in the main form of complexes; free
state accounts for a few proportion.
Chemical Properties
Light yellow to greenish-yellow powder
Physical properties
Appearance: yellow crystal. The crystal from the concentrated solution does not
contain crystal water, and the crystal from the dilute solution contains one molecule
crystal water. Melting point: 223?225?°C. Solubility: It is slightly soluble in cold
water but soluble in hot water, cold ethanol, and ethyl acetate. The basic solution is
orange-red. Ferric chloride solution was dark green.
Uses
Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi.
Indications
It is used for preventing or stopping bleeding during surgery, as well as hemostasis in the department of medicine, obstetrics and gynecology, etc. It is also used for various causes of neutropenia and thrombocytopenia.
General Description
Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.
Air & Water Reactions
Insoluble in water.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Caffeic acid emits acrid smoke and fumes.
Fire Hazard
Flash point data for Caffeic acid are not available; however, Caffeic acid is probably combustible.
Purification Methods
Recrystallise this antioxidant from water. [Beilstein 10 IV 1776.]
Caffeic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| SVH BIOSCIENCES | 58 |
| SREE SYNERIC LAB | 58 |
| AVIGYABIOSCIENCES PRIVATE LIMITED | 58 |
| Dr. ASCRO Bio Sciences Private Limited | 58 |
| Laurus Labs Ltd | 58 |
| P C Chem | 58 |
| Molychem | 58 |
| CHEMSWORTH | 30 |
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