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ChemicalBook >제품 카탈로그 >생화학 공학>억제제>GPCR & G 단백질>아데노신 수용체 길항제>8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 구조식 이미지
카스 번호:
155270-99-8
상품명:
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
동의어(영문):
CS-285;KW-6002;Itraphylline;stradefylline;istradefylline;10mg 50mg 100mg 1g 5g;Istradefylline-13C-d3;KW6002/Istradefylline;Istradefylline (KW-6002);Itraphylline impurities5
CBNumber:
CB11261287
분자식:
C20H24N4O4
포뮬러 무게:
384.43
MOL 파일:
155270-99-8.mol

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 속성

녹는점
191 °C
끓는 점
601.0±65.0 °C(Predicted)
밀도
1.24±0.1 g/cm3(Predicted)
저장 조건
2-8°C
용해도
DMSO: 가용성5mg/mL(투명 용액)
물리적 상태
가루
산도 계수 (pKa)
0.47±0.70(Predicted)
색상
흰색에서 베이지색
InChIKey
IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS 데이터베이스
155270-99-8
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 25
안전지침서 45
유엔번호(UN No.) UN 2811 6.1 / PGIII
WGK 독일 3
HS 번호 2933.99.7500
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
2 0

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione C화학적 특성, 용도, 생산

개요

In March 2013, istradefylline (also known as KW-6002) was approved in Japan for adjunctive treatment of Parkinson’s disease (PD). Istradefylline acts by antagonism of the adenosine A2A receptor, which is colocalized with dopamine D2 receptors in the striatum, to enhance dopamine D2-dependent signaling. Istradefylline is a light-sensitive compound and has been evaluated in vitro under low-light conditions to prevent isomerization of the (E)-styryl group and decomposition. Istradefylline has a Ki of 2.2 nM for the rat adenosine A2A receptor and an ED50 of 0.03 mg/kg, po, in reversal of haloperidol-induced catalepsy in mice. Further characterization showed istradefylline to have a Ki of 12 nM for the human adenosine A2A receptor, to be highly selective, and to be a functional competitive antagonist. Istradefylline has activity alone and in combination with levo-dopa in preclinical animal models of PD. The synthesis of istradefylline was accomplished by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated coupling of 5,6-diamino-1,3-diethyluracil with 3,4-dimethoxycinnamic acid, followed by cyclization upon treatment with aqueous NaOH, and selective methylation (MeI, K2CO3, and DMF).

용도

Treatment of Parkinson’s disease (adenosine A 2A receptor antagonist).

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 준비 용품 및 원자재

원자재

준비 용품

8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 공급 업체

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8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 관련 검색:

Itraconazole 1H-Purine-2,6-dione,8-[2-(3,4-dihydroxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-, (E)-(9CI) Istradefylline Impurity 2 3-(3,4-Dimethoxyphenyl)propenamide 4-DesMethyl Istradefylline Istradefylline Impurity 5 1,3-DIETHYL-5,6-DIAMINOURACIL 1,3-DIETHYL-5-NITROSO-6-AMINOURACIL 1,3-DIETHYL-6-AMINOURACIL Caffeic acid 3-Desmethyl Istradefylline Istradefylline Dimer 2 Istradefylline Impurity 10 6-Aminouracil 3,4-Dimethoxycinnamic acid Everolimus Selumetinib U0126-EtOH
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