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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Immunosuppressants >Tacrolimus

Tacrolimus

Tacrolimus Structure
  • ₹11730 - ₹23487.8
  • Product name: Tacrolimus
  • CAS: 104987-11-3
  • MF: C44H69NO12
  • MW: 804.02
  • EINECS:1308068-626-2
  • MDL Number:MFCD00869853
  • Synonyms:(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s* ;,19s*,26ar*))- ;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1 ;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;L 679934;FK-506:FR-900506;Fujimycin Prozraf;Tacrolimus,micronisedandpharmagrade
3 prices
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Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 1ML
  • ManufacturerSigma-Aldrich
  • Product number342500
  • Product descriptionFK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.
  • Packaging5MG
  • Price₹11730
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number342500
  • Product descriptionFK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.
  • Packaging5MG
  • Price₹11730
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT-049
  • Product descriptionTacrolimus solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹23487.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 342500 FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. 5MG ₹11730 2022-06-14 Buy
Sigma-Aldrich(India) 342500 FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. 5MG ₹11730 2022-06-14 Buy
Sigma-Aldrich(India) T-049 Tacrolimus solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹23487.8 2022-06-14 Buy

Properties

Melting point :113-115°C
Boiling point :871.7±75.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: >3 mg/mL
form :solid
pka :9.97±0.70(Predicted)
color :white
Water Solubility :Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
BCS Class :2
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey :QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS DataBase Reference :104987-11-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. It is also used in the treatment of other T cell-mediated diseases such as eczema, Kimura's disease and Cushing's syndrome. Further, it is used as a research tool in chemically induced dimerization applications. In addition, it is used in liver transplantation and to suppress the inflammation in ulcerative cells. In dermatology, it is used as an ointment to treat eczema especially atopic dermatitis.

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