Tacrolimus manufacturers and suppliers in india

Tacrolimus

Properties

Melting point:: 113-115°C

Boiling point:: 871.7±75.0 °C(Predicted)

Density: 1.19±0.1 g/cm3(Predicted)

Flash point:: 2℃

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: DMSO: >3 mg/mL

form: solid

pka: 9.97±0.70(Predicted)

color: white

Water Solubility: Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.

BCS Class: 2

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

InChIKey: QJJXYPPXXYFBGM-LFZNUXCKSA-N

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H361f-H373

Precautionary statements: P202-P260-P264-P270-P280-P301+P310

Hazard Codes: T,Xi,Xn,F

Risk Statements: 25-36/37/38-36-20/21/22-11

Safety Statements: 45-36-26-36/37-16-60-20

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: KD4201200

HazardClass: 6.1

HS Code: 29349990

Use

FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system. Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.