Tacrolimus
Tacrolimus
- CAS:
- 104987-11-3
- MF:
- C44H69NO12
- MW:
- 804.02
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Company Type
Properties
- Melting point:
- 113-115°C
- Boiling point:
- 871.7±75.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- Flash point:
- 2℃
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: >3 mg/mL
- form
- solid
- pka
- 9.97±0.70(Predicted)
- color
- white
- optical activity
- +62.223 (CHCl3)
- Water Solubility
- Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
- BCS Class
- 2
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- InChIKey
- QJJXYPPXXYFBGM-LFZNUXCKSA-N
- CAS DataBase Reference
- 104987-11-3(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H301-H361f-H373
- Precautionary statements
- P202-P260-P264-P270-P280-P301+P310
- Hazard Codes
- T,Xi,Xn,F
- Risk Statements
- 25-36/37/38-36-20/21/22-11
- Safety Statements
- 45-36-26-36/37-16-60-20
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- KD4201200
- HazardClass
- 6.1
- HS Code
- 29349990
- Hazardous Substances Data
- 104987-11-3(Hazardous Substances Data)
Use
FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system. Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.
20 India supplier list of "Tacrolimus"
- Product Name:Tacrolimus
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: AndhraPradesh,INDIA
- Product Name:Tacrolimus
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Tacrolimus
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Tacrolimus
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Tacrolimus
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Tacrolimus
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Madhya Pradesh,INDIA
- Product Name:TACROLIMUS
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:FK-506,Streptomycessp.-CAS104987-11-3-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:342500 | Purity:ImmunosuppressantthatblocksTcellproliferationinvitrobyinhibitingthegenerationofs
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Tacrolimus 95.00%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.079434
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Tacrolimus
- Company Type: Trader
- Country/Region: New Delhi,INDIA