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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Standard Substance >Ascomycin

Ascomycin

Ascomycin Structure
  • ₹26240.9 - ₹27679.53
  • Product name: Ascomycin
  • CAS: 104987-12-4
  • MF: C43H69NO12
  • MW: 792.01
  • EINECS:600-627-5
  • MDL Number:MFCD06198665
  • Synonyms:15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram;C058028;L 683590, FR 900520, IMMunoMycin, FK 520, WS 7238A, NSC 106410;Ascomycin:Tacrolimus Desmethylene Impurit;Tacrolimus USP RC A;FK-520;FR-900520;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberA-094
  • Product descriptionAscomycin solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹26240.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3835
  • Product descriptionAscomycin from Streptomyces hygroscopicus var. ascomyceticus
  • Packaging1MG
  • Price₹27679.53
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A-094 Ascomycin solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹26240.9 2022-06-14 Buy
Sigma-Aldrich(India) A3835 Ascomycin from Streptomyces hygroscopicus var. ascomyceticus 1MG ₹27679.53 2022-06-14 Buy

Properties

Melting point :153-157°C
Boiling point :868℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
form :Powder
pka :9.97±0.70(Predicted)
color :White to off-white
Water Solubility :Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
InChIKey :ZDQSOHOQTUFQEM-AMASXYNMSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).

Description

Ascomycin, produced by the fermentation of S. hygroscopicus subsp. ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FK-506-binding protein 12 (FKBP12), an immunophilin that acts as the principal mediator of FK506- and rapamycin-induced immunosuppression. Ascomycin inhibits the enzymatic peptidyl-prolyl cis-trans isomerase and chaperone activities of PfFKBP35, an FKBP from P. falciparum, a causative agent of malaria in humans with an IC50 value of 0.52 μM.

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