Ascomycin
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- ₹26240.9 - ₹27679.53
- Product name: Ascomycin
- CAS: 104987-12-4
- MF: C43H69NO12
- MW: 792.01
- EINECS:600-627-5
- MDL Number:MFCD06198665
- Synonyms:15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram;C058028;L 683590, FR 900520, IMMunoMycin, FK 520, WS 7238A, NSC 106410;Ascomycin:Tacrolimus Desmethylene Impurit;Tacrolimus USP RC A;FK-520;FR-900520;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 1ML
- ManufacturerSigma-Aldrich(India)
- Product numberA-094
- Product descriptionAscomycin solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging1ML
- Price₹26240.9
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA3835
- Product descriptionAscomycin from Streptomyces hygroscopicus var. ascomyceticus
- Packaging1MG
- Price₹27679.53
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | A-094 | Ascomycin solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 1ML | ₹26240.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | A3835 | Ascomycin from Streptomyces hygroscopicus var. ascomyceticus | 1MG | ₹27679.53 | 2022-06-14 | Buy |
Properties
Melting point :153-157°C
Boiling point :868℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
form :Powder
pka :9.97±0.70(Predicted)
color :White to off-white
Water Solubility :Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
InChIKey :ZDQSOHOQTUFQEM-AMASXYNMSA-N
Boiling point :868℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
form :Powder
pka :9.97±0.70(Predicted)
color :White to off-white
Water Solubility :Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
InChIKey :ZDQSOHOQTUFQEM-AMASXYNMSA-N
Safety Information
Symbol(GHS): |
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Description
Ascomycin, produced by the fermentation of S. hygroscopicus subsp. ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FK-506-binding protein 12 (FKBP12), an immunophilin that acts as the principal mediator of FK506- and rapamycin-induced immunosuppression. Ascomycin inhibits the enzymatic peptidyl-prolyl cis-trans isomerase and chaperone activities of PfFKBP35, an FKBP from P. falciparum, a causative agent of malaria in humans with an IC50 value of 0.52 μM.Related product price
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