Chidamide
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- ₹0
- Product name: Chidamide
- CAS: 743420-02-2
- MF: C22H19FN4O2
- MW: 390.41
- EINECS:
- MDL Number:
- Synonyms:(E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide Chidamide;Chidamide;(E)-N-(2-aMino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzaMide;N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl]benzamide;De-4-fluoro 5-Fluoro Chidamide;CHIDAMIDE;(E)-N-(2-AMINO-5-FLUOROPHENYL)-4-((3-(PYRIDIN-3-YL)ACRYLAMIDO)METHYL)BENZAMIDE;(E)-N-(2-AMINO-5-FLUOROPHENYL)-4-((3-(PYRIDIN-3-YL)ACRYLAMIDO)METHYL)BENZAMIDE CHIDAMIDE;N-(2-AMINO-5-FLUOROPHENYL)-4-[[[1-OXO-3-(3-PYRIDINYL)-2-PROPENYL]AMINO]METHYL;N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl;Chidamide D4
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Properties
Melting point :>145°C (dec.)
Boiling point :600.2±55.0 °C(Predicted)
Density :1.336±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Sonicated)
form :Solid
pka :12.30±0.70(Predicted)
color :Off-White to Pale Beige
Boiling point :600.2±55.0 °C(Predicted)
Density :1.336±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Sonicated)
form :Solid
pka :12.30±0.70(Predicted)
color :Off-White to Pale Beige
Safety Information
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Description
Chidamide is a histone deacetylase inhibitor that increases histone H3 acetylation levels in LoVo and HT-29 colon cancer cells at concentrations as low as 4 μM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells. Furthermore, chidamide treatment dose-dependently upregulates p21 protein expression, downregulates Cdk4, and induces cell cycle arrest at the G0/G1 phase.Related product price
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