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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >DNA damage >PARP inhibitors >Veliparib

Veliparib

Veliparib Structure
  • ₹0
  • Product name: Veliparib
  • CAS: 912444-00-9
  • MF: C13H16N4O
  • MW: 244.29
  • EINECS:681-636-1
  • MDL Number:MFCD16661059
  • Synonyms:2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide;1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-;2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide;A861695;2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide;ABT-888 (Veliparib, NSC 737664);Veliparib(chiral);2-[(R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :579.0±40.0 °C(Predicted)
Density :1.274
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
form :solid
pka :9.22±0.30(Predicted)
color :White to off-white
CAS DataBase Reference :912444-00-9

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.

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