PF-01367338
|
- ₹0
- Product name: PF-01367338
- CAS: 459868-92-9
- MF: C19H21FN3O5P
- MW: 421.37
- EINECS:-0
- MDL Number:MFCD17010269
- Synonyms:AG-014699;AG-014699;PF-01367338;PF-01367338;AG14699;8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate;Rucaparib (AG-014699 , PF-01367338);Rucaparib phosphate;AG-014699 (Rucaparib)
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Melting point :>173°C (dec.)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Yellow solid.
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Yellow solid.
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is used as a therapeutic strategy to selectively target cancers. Rucaparib is a potent, cell-permeable inhibitor of PARP-1 (Ki = <5 nM) that is used in clinical therapy to sensitize cancer cells to chemotherapy. Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM. At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors. It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts. Rucaparib (phosphate) is the phosphate salt of rucaparib and has improved aqueous solubility.More related product prices
Olaparib 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one Rapamycin 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide BMN 673 MK-2206 2HCl Everolimus 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- NU1025 3-Aminobenzamide 4-AMINO-1,8-NAPHTHALIMIDE ABT-888 Ruxolitinib 283173-50-2 Ruxolitinib phosphate 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- TIQ-ARelated product price
- Rapamycin
₹4194-370089 - Everolimus
₹11709-51483.7 - NU1025
₹20250-24583.58
